673855-63-5Relevant academic research and scientific papers
Rotational-echo double-resonance NMR distance measurements for the tubulin-bound paclitaxel conformation
Paik, Younkee,Yang, Chao,Metaferia, Belhu,Tang, Shoubin,Bane, Susan,Ravindra, Rudravajhala,Shanker, Natasha,Alcaraz, Ana A.,Johnson, Scott A.,Schaefer, Jacob,O'Connor, Robert D.,Cegelski, Lynette,Snyder, James P.,Kingston, David G. I.
, p. 361 - 370 (2008/02/09)
The important anticancer drug Taxol (paclitaxel, PTX) owes its unique activity to its ability to bind to tubulin in a stoichiometric ratio and promote its assembly into microtubules. The conformation of the microtubule-bound drug has been the focus of num
Lipase-catalyzed resolution of 4-aryl-substituted β-lactams: Effect of substitution on the 4-aryl ring
Carr, Jason A.,Al-Azemi, Talal F.,Long, Timothy E.,Shim, Jeung-Yeop,Coates, Cristina M.,Turos, Edward,Bisht, Kirpal S.
, p. 9147 - 9160 (2007/10/03)
Pseudomonas cepacia lipase (PS-30) was used in hydrolytic resolution of 3-acetoxy-4-aryl-substituted azetidin-2-ones (>97% ee). Twenty-three β-lactam substrates with varied substituents at the C-4 center of the ring were synthesized and subjected to lipas
