67404-82-4Relevant academic research and scientific papers
MANNICH AND GRIGNARD REACTION OF SOME N-(2-PROPYNYL) AZAHETEROCYCLES
Silhankova, Alexandra,Hoskovec, Michal,Liboska, Radek,Ferles, Miloslav
, p. 1067 - 1081 (2007/10/02)
1,4-Disubstituted butynes IV-VII were prepared by Mannich reaction of N-(2-propynyl) derivatives of 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroisoquinoline, piperidine and azacycloheptane with polyoxymethylene and another heterocyclic amines.Reaction of 3-(1-piperidinyl)-1-propynylmagnesium bromide or 3-(1-azacycloheptyl)-1-propynylmagnesium bromide afforded alcohols X-XIII.
