67434-28-0

Usage

InChI:InChI=1/C8H12N2O/c1-9-7-8(11)10-5-3-2-4-6-10/h2-7H2

Upstream product

• 110-89-4 piperidine 
• 39687-95-1 isocyanoacetic acid methyl ester 
• 2999-46-4 Ethyl isocyanoacetate 

Downstream Products

• 84977-70-8 α-formylaminocyclohexylideneacetylpiperidine 
• 76203-42-4 5-(4-chlorophenyl)-2-oxazoline-4-carboxamoylpiperidine 
• 76304-37-5 [3-(4-Methoxy-phenyl)-4-(piperidine-1-carbonyl)-1H-pyrrol-2-yl]-piperidin-1-yl-methanone 
• 76304-36-4 [3-(4-Dimethylamino-phenyl)-4-(piperidine-1-carbonyl)-1H-pyrrol-2-yl]-piperidin-1-yl-methanone 
• 121687-15-8 ((4S,5R)-5-Phenyl-4,5-dihydro-oxazol-4-yl)-piperidin-1-yl-methanone 
• 121687-15-8 ((4R,5S)-5-Phenyl-4,5-dihydro-oxazol-4-yl)-piperidin-1-yl-methanone 
• 121687-15-8 ((4S,5S)-5-Phenyl-4,5-dihydro-oxazol-4-yl)-piperidin-1-yl-methanone 
• 121687-20-5 3,5-Dinitro-benzoic acid (1R,2R)-2-(3,5-dinitro-benzoylamino)-3-oxo-1-phenyl-3-piperidin-1-yl-propyl ester 
• 76304-65-9 N-[(Z)-2-(4-Methoxy-phenyl)-1-(piperidine-1-carbonyl)-vinyl]-formamide 
• 99506-25-9 N-[1-(4-Methyl-cyclohexylidene)-2-oxo-2-piperidin-1-yl-ethyl]-formamide 
• 99506-30-6 α-formylaminocyclopentylideneacetylpiperidine 
• 76304-64-8 N-[(Z)-2-(4-Dimethylamino-phenyl)-1-(piperidine-1-carbonyl)-vinyl]-formamide 
• 76203-41-3 N-[(Z)-2-(3,4-Dichloro-phenyl)-1-(piperidine-1-carbonyl)-vinyl]-formamide 
• 99506-22-6 α-formylaminocycloheptylideneacetylpiperidine 

Relevant academic research and scientific papers

Silver-Catalyzed Chemoselective [4+2] Annulation of Two Isocyanides: A General Route to Pyridone-Fused Carbo- and Heterocycles

A silver-catalyzed chemoselective [4+2] annulation of aryl and heteroaryl isocyanides with α-substituted isocyanoacetamides was developed for the facile and efficient synthesis of 2-aminoquinolones, naphthyridines, and phenanthrolines. A mechanism for this multistep domino reaction is proposed on the basis of a13C-labeling experiment, according to which an unprecedented chemoselective heterodimerization of two different isocyanides generates an α-amidoketenimine intermediate, which undergoes 1,3-amino migration to form an α-imidoylketene, followed by 6 π electrocyclization.

Easy Synthesis of Two Positional Isomeric Tetrazole Libraries

A fast and efficient synthesis of libraries of positional isomeric 1H-tetrazoles and 5H-tetrazoles, for the purpose of testing binding hypothesis of isomeric tetrazoles in fragment-based drug discovery, is described.

3-(4-FLUOROPHENYL)-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS HAVING ANALGESIC ACTIVITY

Compounds according to the formula below are disclosed herein: Therapeutic methods for the treatment of pain, compositions, and medicaments related thereto are also disclosed.

METHODS FOR TREATING CHRONIC PAIN USING 3-ARYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES, 3-HETEROARYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from one or more types of chronic pain using compounds of Formulas 1 and 2 wherein the variables have the meaning disclosed in the specification

2-SUBSTITUTED 3-(4-AMIDINOPHENYL)PROPIONIC ACID DERIVATIVES

2-Substituted 3-(4-amidinophenyl)propionic acid derivatives of the formula STR1 in which A, Ar and B have the meanings stated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.

Synthesis and Herbicidal Activities of &α-Isocyanocycloalkylideneacetamides

Various α-isocyanocycloalkylideneacetamides were synthetised by the reaction of isocyanoacetamides with ketones following by dehydration.These compounds were examined for their inhibitory activity against the germination of rice, cucumber and radish seeds