67434-28-0

Basic information

• Product Name: N-PIPERIDINO-2-ISOCYANO-ACETAMIDE
• Synonyms: N-PIPERIDINO-2-ISOCYANO-ACETAMIDE;2-isocyano-1-(1-piperidinyl)ethanone;2-isocyano-1-piperidin-1-ylethanone
• CAS NO: 67434-28-0
• Molecular Formula: C₈H₁₂N₂O
• Molecular Weight: 152.19
• Mol File: 67434-28-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: N-PIPERIDINO-2-ISOCYANO-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-PIPERIDINO-2-ISOCYANO-ACETAMIDE(67434-28-0)
• EPA Substance Registry System: N-PIPERIDINO-2-ISOCYANO-ACETAMIDE(67434-28-0)

Safety Data

• Hazardous Substances Data: 67434-28-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H12N2O/c1-9-7-8(11)10-5-3-2-4-6-10/h2-7H2

Upstream product

• 110-89-4 piperidine 
• 39687-95-1 isocyanoacetic acid methyl ester 
• 2999-46-4 Ethyl isocyanoacetate 

Downstream Products

• 76304-37-5 [3-(4-Methoxy-phenyl)-4-(piperidine-1-carbonyl)-1H-pyrrol-2-yl]-piperidin-1-yl-methanone 
• 76304-36-4 [3-(4-Dimethylamino-phenyl)-4-(piperidine-1-carbonyl)-1H-pyrrol-2-yl]-piperidin-1-yl-methanone 
• 121687-20-5 3,5-Dinitro-benzoic acid (1R,2R)-2-(3,5-dinitro-benzoylamino)-3-oxo-1-phenyl-3-piperidin-1-yl-propyl ester 
• 99506-30-6 α-formylaminocyclopentylideneacetylpiperidine 
• 76304-65-9 N-[(Z)-2-(4-Methoxy-phenyl)-1-(piperidine-1-carbonyl)-vinyl]-formamide 
• 120302-02-5 C₂₁H₂₂N₂O₂ 
• 76304-69-3 (Z)-2-isocyano-3-(4-methoxyphenyl)-1-(piperidin-1-yl)prop-2-en-1-one 
• 1610565-48-4 (1,4-diphenylisoquinolin-3-yl)(piperidin-1-yl)methanone 
• 1610565-49-5 (7-methoxy-1-phenylisoquinolin-3-yl)(piperidin-1-yl)methanone 
• 1610565-63-3 (1-(4-chlorophenyl)-4-phenylisoquinolin-3-yl)(piperidin-1-yl)methanone 
• 76203-10-6 (Z)-3-(3,4-Dichloro-phenyl)-2-isocyano-1-piperidin-1-yl-propenone 
• 76304-68-2 (Z)-3-(4-Dimethylamino-phenyl)-2-isocyano-1-piperidin-1-yl-propenone 
• 76203-08-2 (Z)-3-(4-Chloro-phenyl)-2-isocyano-1-piperidin-1-yl-propenone 

Relevant articles and documents

Silver-Catalyzed Chemoselective [4+2] Annulation of Two Isocyanides: A General Route to Pyridone-Fused Carbo- and Heterocycles

A silver-catalyzed chemoselective [4+2] annulation of aryl and heteroaryl isocyanides with α-substituted isocyanoacetamides was developed for the facile and efficient synthesis of 2-aminoquinolones, naphthyridines, and phenanthrolines. A mechanism for this multistep domino reaction is proposed on the basis of a13C-labeling experiment, according to which an unprecedented chemoselective heterodimerization of two different isocyanides generates an α-amidoketenimine intermediate, which undergoes 1,3-amino migration to form an α-imidoylketene, followed by 6 π electrocyclization.

3-(4-FLUOROPHENYL)-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS HAVING ANALGESIC ACTIVITY

Compounds according to the formula below are disclosed herein: Therapeutic methods for the treatment of pain, compositions, and medicaments related thereto are also disclosed.

2-SUBSTITUTED 3-(4-AMIDINOPHENYL)PROPIONIC ACID DERIVATIVES

2-Substituted 3-(4-amidinophenyl)propionic acid derivatives of the formula STR1 in which A, Ar and B have the meanings stated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.