674368-75-3Relevant academic research and scientific papers
New aromatic monoesters of α-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13
Grzywa, Renata,Sokol, Anna M.,Sieńczyk, Marcin,Radziszewicz, Magdalena,Ko?cio?ek, Beata,Carty, Michael P.,Oleksyszyn, Józef
experimental part, p. 2930 - 2936 (2010/07/04)
A series of new aromatic monoesters of α-aminoaralkylphosphonic acids were synthesized by selective hydrolysis of corresponding aromatic diesters of α-aminoaralkylphosphonic acids. New potential inhibitors of aminopeptidase N/CD13, an enzyme important in tumour angiogenesis, were developed. Some derivatives of the homophenylalanine and norleucine related monoaryl phosphonates displayed higher inhibition potency than corresponding α-aminoaralkylphosphonic acids toward aminopeptidase N/CD13. The effect of one of the new inhibitors on the growth of human PANC-1 and HT-1080 cell lines was examined, either alone or in combination with TNF-α.
