67443-05-4Relevant academic research and scientific papers
Antimicrobial studies of some novel quinazolinones fused with [1,2,4]-triazole, [1,2,4]-triazine and [1,2,4,5]-tetrazine rings
Pandey, Sarvesh Kumar,Singh, Abhishek,Singh, Ashutosh,Nizamuddin
experimental part, p. 1188 - 1197 (2009/09/30)
Three series of novel and new fused heterocyclic systems, viz. triazolo[4,3-a]-quinazolin-7-ones (4), [1,2,4,5]-tetrazino[4,3-a]-quinazolin-8-ones (6) and indolo[2,3-c][1,2,4]-triazino[4,3-a]-quinazolin-8-ones (8) have been synthesized from the key intermediate 3-(substituted-phenyl)-2-hydrazino-quinazolin-4-ones (3). Thus, condensation of (3) with appropriate aromatic acids in the presence of DCC in dichloromethane afforded the fused system (4), while reaction of (3) with isatin in methanol gave the corresponding Schiff base (7) which on cyclodehydration furnished another fused heterocyclic system (8). The intermediate (3) on refluxing with substituted-phenylisothiocyanate gave the substituted-thiosemicarbazide (5), which on oxidative cyclization with bromine in CCl4 furnished the novel fused system (6). The structures of intermediate and final compounds have been determined by means of IR, 1H NMR, 13C NMR, UV and elemental analysis. All the synthesized compounds have been screened for their antibacterial activity against Gram-negative bacteria, Escherichia coli, Pseudomonas aeruginosa and Gram-positive bacteria, Streptococcus pneumoniae, Bacillus subtilis, as well as demonstrated significant antifungal activity against fungi viz. Candida albicans, Aspergillus fumigatus, Aspergillus flavus, and Aspergillus niger.
Synthesis of some novel quinazolone thiosemicarbazide and thiazoline derivatives for potential antimicrobial activity
Omar, A.-Mohsen M. E.,El-Dine, S. A. Shams,Ghobashy, A. A.,Khalil, M. A.
, p. 77 - 80 (2007/10/02)
Various quinazolone thiosemicarbazide and thiazoline derivatives were prepared.Significant in vitro Gram-positive antibacterial activities were observed for some members of the series.The activity of some products was as potent as that of penicillin.
