67451-81-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Morpholin-4-ylmethylbenzoic acid is used as an antitumor agent for its potential in treating cancer. It has been studied for its ability to inhibit tumor growth and progression, offering a promising avenue for cancer therapy.
Used in Antifungal Applications:
In the field of antifungal medicine, 3-Morpholin-4-ylmethylbenzoic acid is used as an antifungal agent to combat fungal infections, providing a potential therapeutic solution for various fungal diseases.
Used in Metabolic Regulation Research:
3-Morpholin-4-ylmethylbenzoic acid is utilized in research as a metabolic regulator, exploring its potential to influence cellular metabolism and energy balance, which could have implications for the development of treatments for metabolic disorders.

InChI:InChI=1/C12H15NO3/c14-12(15)11-3-1-2-10(8-11)9-13-4-6-16-7-5-13/h1-3,8H,4-7,9H2,(H,14,15)

Upstream product

• 190660-95-8 methyl 3-((morpholin-4-yl)methyl)benzoate 
• 1129-28-8 3-methoxycarbonylbenzyl bromide 
• 99-36-5 1-methoxycarbonyl-3-methylbenzene 
• 110-91-8 morpholine 

Downstream Products

• 913976-18-8 6β,9α-dihydroxy-8,13-epoxy-7β-[3-(4-morpholinomethyl)benzoyloxy]-1α-tert-butyldimethylsilyloxy-labd-14-en-11-one 
• 748099-99-2 3-(morpholinomethyl)benzoyl chloride 
• 1016195-15-5 C₃₁H₃₂FN₅O₅ 
• 299181-00-3 2,2'-[(E)-1,2-ethenediyl]bis[5-[[3-(4-morpholinylmethyl)benzoyl]amino]benzenesulfonic acid] 

Relevant academic research and scientific papers

New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities

An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested in vitro for their activities against blood stages of two strains of Plasmodium falciparum. Several structure–activity relationships were revealed. The activity strongly depended on the nature of the acyl moiety. Only benzamides showed promising activity. The substitution pattern of their phenyl ring affected the activity and the cytotoxicity of compounds. In addition, physicochemical parameters were calculated (log P, log D, ligand efficiency) or determined experimentally (permeability) via a PAMPA. The N-(4-(3,4-diethoxyphenyl)-1,2,5-oxadiazol-3-yl)-3(trifluoromethyl)benzamide possessed good physicochemical properties and showed high antiplasmodial activity against a chloroquine-sensitive strain (IC50 (NF54) = 0.019 μM) and even higher antiplasmodial activity against a multiresistant strain (IC50 (K1 ) = 0.007 μM). Compared to the MMV compound, the permeability and the activity against the multiresistant strain were improved.

COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF

The present invention provides modulators of protein function, to restore protein homeostasis, including GSPT1 activity. The invention provides methods of modulating protein-mediated diseases, such as GSPT1-mediated diseases, disorders, conditions, or responses. Compositions are also provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, and conditions, such as GSPT1-mediated diseases, disorders, and conditions, including cancer and astrogliosis.

Aryl sulfonic acids and derivatives as FSH antagonists

This invention provides compounds of formula I having the structure wherein R1, Ar, Ar′, and Q are as defined in the specification, or a pharmaceutically acceptable salt thereof, which are useful as contraceptive agents.