67451-81-4

Basic information

• Product Name: 3-MORPHOLIN-4-YLMETHYLBENZOIC ACID
• Synonyms: 3-MORPHOLIN-4-YLMETHYLBENZOIC ACID;AKOS BB-9413;3-Morpholin-4-ylmethylbenzoicacid95%;3-MORPHOLIN-4-YLMETHYLBENZOIC ACID 95%;3-(4-Morpholinylmethyl)Benzoic acid;3-(Morpholinomethyl)benzoic Acid;3-(Morpholinomethyl)
• CAS NO: 67451-81-4
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.25
• Mol File: 67451-81-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 376.9 °C at 760 mmHg
• Flash Point: 181.8 °C
• Appearance: /
• Density: 1.233 g/cm³
• Vapor Pressure: 2.37E-06mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.98±0.10(Predicted)
• CAS DataBase Reference: 3-MORPHOLIN-4-YLMETHYLBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-MORPHOLIN-4-YLMETHYLBENZOIC ACID(67451-81-4)
• EPA Substance Registry System: 3-MORPHOLIN-4-YLMETHYLBENZOIC ACID(67451-81-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 67451-81-4(Hazardous Substances Data)

Usage

General Description

3-Morpholin-4-ylmethylbenzoic acid, also known as BML-284, is a chemical compound that belongs to the category of benzoic acids. It is a synthetic compound that contains a morpholine ring, which is a heterocyclic organic compound, and a benzene ring. BML-284 has been studied for its potential therapeutic applications, particularly in the field of medicine and pharmacology. It is known to exhibit antitumor and antifungal activities, and has been investigated for its potential use in the treatment of cancer and fungal infections. Additionally, BML-284 is also being researched for its potential role in the regulation of cellular metabolism and energy balance. Overall, 3-Morpholin-4-ylmethylbenzoic acid is a compound of interest for various biomedical and pharmaceutical studies due to its unique chemical structure and potential therapeutic properties.

InChI:InChI=1/C12H15NO3/c14-12(15)11-3-1-2-10(8-11)9-13-4-6-16-7-5-13/h1-3,8H,4-7,9H2,(H,14,15)

Upstream product

• 110-91-8 morpholine 
• 1129-28-8 3-methoxycarbonylbenzyl bromide 
• 99-36-5 1-methoxycarbonyl-3-methylbenzene 
• 190660-95-8 methyl 3-((morpholin-4-yl)methyl)benzoate 

Downstream Products

• 748099-99-2 3-(morpholinomethyl)benzoyl chloride 
• 1016195-15-5 C₃₁H₃₂FN₅O₅ 
• 299181-00-3 2,2'-[(E)-1,2-ethenediyl]bis[5-[[3-(4-morpholinylmethyl)benzoyl]amino]benzenesulfonic acid] 
• 913976-18-8 6β,9α-dihydroxy-8,13-epoxy-7β-[3-(4-morpholinomethyl)benzoyloxy]-1α-tert-butyldimethylsilyloxy-labd-14-en-11-one 

Relevant articles and documents

New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities

An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested in vitro for their activities against blood stages of two strains of Plasmodium falciparum. Several structure–activity relationships were revealed. The activity strongly depended on the nature of the acyl moiety. Only benzamides showed promising activity. The substitution pattern of their phenyl ring affected the activity and the cytotoxicity of compounds. In addition, physicochemical parameters were calculated (log P, log D, ligand efficiency) or determined experimentally (permeability) via a PAMPA. The N-(4-(3,4-diethoxyphenyl)-1,2,5-oxadiazol-3-yl)-3(trifluoromethyl)benzamide possessed good physicochemical properties and showed high antiplasmodial activity against a chloroquine-sensitive strain (IC50 (NF54) = 0.019 μM) and even higher antiplasmodial activity against a multiresistant strain (IC50 (K1 ) = 0.007 μM). Compared to the MMV compound, the permeability and the activity against the multiresistant strain were improved.

Aryl sulfonic acids and derivatives as FSH antagonists

This invention provides compounds of formula I having the structure wherein R1, Ar, Ar′, and Q are as defined in the specification, or a pharmaceutically acceptable salt thereof, which are useful as contraceptive agents.