67452-97-5

Basic information

• Product Name: Vaderm
• Synonyms: Alclometasone;Vaderm;ALCLOMETHASONE DIPROPIONATE;7α-Chloro-16α-methylprednisolone;7α-Chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione;(7α,11β,16α)-7-Chloro-11,17,21-trihydroxy-16-Methylpregna-1,4-diene-3,20-dione;AlcloMethasone
• CAS NO: 67452-97-5
• Molecular Formula: C22H29ClO5
• Molecular Weight: 408.919
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids
• Mol File: 67452-97-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 176-179°
• Boiling Point: 607.1°Cat760mmHg
• Flash Point: 320.9°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 2.85E-17mmHg at 25°C
• Refractive Index: 1.607
• PKA: 12.30±0.70(Predicted)
• CAS DataBase Reference: Vaderm(CAS DataBase Reference)
• NIST Chemistry Reference: Vaderm(67452-97-5)
• EPA Substance Registry System: Vaderm(67452-97-5)

Safety Data

• Hazardous Substances Data: 67452-97-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 67452-97-5 differently. You can refer to the following data:
1. As a metabolite of Alclometasone dipropionate; Alclometasone can be used as a synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
2. A metabolite of Alclometasone dipropionate (A514580); a synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasocons trictive agent.
3. A metabolite of Alclometasone dipropionate (A514580); a synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.

Definition

ChEBI: A prednisolone compound having an alpha-chloro substituent at the 7-position and an alpha-methyl substituent at the 16-position.

Brand name

Aclovate (GlaxoSmithKline).

InChI:InChI=1/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1

Upstream product

• 66734-13-2 alclometasone dipropionate 

Relevant articles and documents

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7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor

Novel 3,20-dioxo-7α-halogeno-1,4-pregnadienes are described and their use as anti-inflammatory agents. Preferred are 7α-bromo- and 7α-chloro- derivatives, particularly 7α-bromo- and 7α-chloro-1,4-pregnadienes-11β,17α,21-triol-3,20-dione 17,21-dihydrocarboncarboxylates, the 16-methyl and 16-methylene derivatives thereof being particularly valuable as topical anti-inflammatory agents.