67460-86-0

Basic information

• Product Name: 3.5dibromo-1H-pyrazole
• Synonyms: 3.5dibromo-1H-pyrazole;3,5-dibromo-1H-pyrazole(WXC07881);3,5-Bibromo-1H-pyrazole
• CAS NO: 67460-86-0
• Molecular Formula: C₃H₂Br₂N₂
• Molecular Weight: 225.86938
• EINECS: -0
• Mol File: 67460-86-0.mol

Chemical Properties

• Boiling Point: 321.8±22.0 °C(Predicted)
• Appearance: /
• Density: 2.419±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.76±0.10(Predicted)
• CAS DataBase Reference: 3.5dibromo-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3.5dibromo-1H-pyrazole(67460-86-0)
• EPA Substance Registry System: 3.5dibromo-1H-pyrazole(67460-86-0)

Safety Data

• Hazardous Substances Data: 67460-86-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3,5-dibromo-1H-pyrazole is used as a building block in the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. Its versatile reactivity allows for the creation of diverse organic compounds, contributing to the development of new and improved products in these industries.
Used in Pharmaceutical Industry:
3,5-dibromo-1H-pyrazole is utilized as a key intermediate in the synthesis of pharmaceutical compounds. Its unique structure and reactivity enable the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3,5-dibromo-1H-pyrazole serves as a crucial component in the synthesis of various agrochemicals, such as pesticides and herbicides. Its properties and reactivity contribute to the creation of more effective and environmentally friendly solutions for agricultural challenges.
Used in Heterocyclic Compound Preparation:
3,5-dibromo-1H-pyrazole is employed as a reagent in the preparation of heterocyclic compounds, which are important in various chemical and pharmaceutical applications. Its unique structure allows for the formation of complex heterocyclic systems with potential applications in drug discovery and development.
Used in Coordination Chemistry:
As a ligand in coordination chemistry, 3,5-dibromo-1H-pyrazole plays a significant role in the synthesis of metal complexes. Its properties and reactivity contribute to the development of new materials with potential applications in catalysis, sensing, and other areas of chemistry.

Upstream product

• 1558037-97-0 6-(toluenesulfonyloxy)-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester 
• 17635-44-8 3,4,5-tribromo-1H-pyrazole 
• 98026-81-4 3,5-dibromo-1H-pyrazole-4-carboxylic acid 

Downstream Products

• 1361019-05-7 3,5-bibromo-1-methyl-1H-pyrazole 
• 34199-55-8 2-(3,5-dibromo-pyrazol-1-yl)-propionic acid 

Relevant articles and documents

PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS

The present application provides a compound of formula (I) or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a stereoisomer thereof, or a pharmaceutically acceptable salt of an atropisomer thereof; method for manufacturing said compound, and its therapeutic uses. The present application further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

METHODS FOR THE PREPARATION OF 5-BROMO-2-(3-CHLORO-PYRIDIN-2-YL)-2H-PYRAZOLE-3-CARBOXYLIC ACID

Described herein are novel methods of synthesizing 5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid from pyrazole or pyrazole derivatives. Also described herein are novel reaction intermediates.

Compound with BRD4 inhibitory activity, preparation method and application thereof

The invention discloses a compound with BRD4 inhibitory activity, a preparation method and application thereof. The structure of the compound with the BRD4 inhibitory activity is shown as a formula I, and definitions of substituent groups are shown in the specification and claims. The compound provided by the invention has very high bromodomain protein inhibition activity, especially BRD4 targeted inhibition activity, and can be used for treating or/and preventing related diseases mediated by bromodomain protein.

ISOQUINOLINES AS INHIBITORS OF HPK1

Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES

The invention relates to pyrazolyl substituted tetrahydropyranylsulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES

The invention relates to pyrazolyl substituted tetrahydropyranylsulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES

The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

FUNGICIDAL PYRAZOLES

Disclosed are compounds of Formula (1) and Formula (1A) including all stereoisomers, N oxides, and salts thereof,wherein Q1, Q2, R1, R2, R4, R5 and X are as defined in the disclosure. Also