67463-03-0

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 97792-00-2 (S)-(-)-N-(p-bromobenzyl)-1-phenylethylamine 
• 1244957-79-6 4-(4'-bromophenyl)-4-(N-α-methyl-phenyl)aminobut-1-ene 
• 1612163-25-3 2-(4-bromophenyl)-N,N-diisopropyl-2-(((S)-1-phenylethyl)-amino)acetamide 
• 1612163-22-0 2-(4-bromophenyl)-N,N-diisopropyl-2-(((S)-1-phenylethyl)-amino)acetamide 
• 97792-01-3 (S)-(+)-N-(p-bromobenzylidene)-1-phenylethylamine N-oxide 
• 60143-68-2 (3S)-trans-3-(4-bromo-phenyl)-2-((S)-1-phenyl-ethyl)-oxaziridine 
• 60143-68-2 (3R)-trans-3-(4-bromo-phenyl)-2-((S)-1-phenyl-ethyl)-oxaziridine 
• 135738-63-5 [(4-Bromo-phenyl)-((S)-1-phenyl-ethylamino)-methyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Carbamoyl anion addition to nitrones

The addition of carbamoyl anions derived from N,N-disubstituted formamides and LDA to N-tert-butyl nitrones is described. The reaction was demonstrated with a variety of formamides and nitrones and provided a direct route to α-(N-hydroxy)amino amides. The use of a tert-leucinol derived chiral auxiliary on the nitrone provided products in good diastereoselectivity. Derivatization of the products by tert-butyl deprotection or N-deoxygenation was demonstrated.