67463-35-8Relevant academic research and scientific papers
High Pressure, Temperature, and Solvent Effects on the Rate of the Diels-Alder Reaction of Furan with N-Phenylmaleimide
Kornilov,Kiselev,Anikin,Kolesnikova,Shulyat’ev
, p. 7 - 10 (2019/04/27)
The effects of temperature, solvent nature, and high pressure on the rate of the Diels-Alder reaction of furan with N-phenylmaleimide were studied. A weak acceleration of the title reaction in proton-donor media was observed in comparison to other cycloaddition and ene reactions. The volumes of activation and reaction coincided within the experimental error, in keeping with the presumed cyclic transition state.
A containing chromon structure pyrromonazole Norcantharidin derivative and its preparation method and application
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Paragraph 0033; 0039, (2017/02/09)
The invention belongs to the technical field of norcantharidin derivative, and particularly relates to a chromone structure-containing pyrazole norcantharidin derivative as well as a preparation method and the application of the derivative. According to the preparation method, the structure of norcantharidin is reformed by bromine-substituted chromone phenylhydrazone, and a five-membered ring pyrazole and chromone structure is introduced by a 1, 3-dipolar cycloaddition method, so that the activity of the norcantharidin can be improved. The chromone structure-containing pyrazole norcantharidin derivative can be applied to synthesis of antineoplastic drugs, and has wide application prospect.
Expeditious 'on-water' cycloaddition between N-substituted maleimides and furans
Gil, María Victoria,Luque-Agudo, Verónica,Román, Emilio,Serrano, José Antonio
supporting information, p. 2179 - 2183 (2014/11/08)
Cycloaddition reactions between N-alkyl and N-aryl-substituted maleimides and furan derivatives have been carried out using the 'on-water' methodology. Transformations are faster and products can easily be isolated by simple workup protocols, often in qua
Clay-catalyzed solventless addition reactions of furan with α,β- unsaturated carbonyl compounds
Avalos, Martin,Babiano, Reyes,Bravo, Jose L.,Cintas, Pedro,Jimenez, Jose L.,Palacios, Juan C.
, p. 9301 - 9304 (2007/10/03)
The reaction of furan with α,β-unsaturated carbonyl dienophiles catalyzed by K10 montmorillonite in the absence of organic solvents produces the corresponding Diels-Alder adducts and, in the case of methyl vinyl ketone, Michael-type products, under much milder conditions than the conventional protocols. The results are consistent with acid catalysis on the clay surface. Acrylates gave lower yields and/or decomposition products. The reaction can be extended to alkynic substrates such as DMAD to afford cycloadducts in good yields.
