67467-27-0

Upstream product

• 56611-62-2 3,5-dimethyl-4-ethoxycarbonyl-phthalic anhydride 
• 77307-59-6 4-ethoxycarbonyl-3,5-dimethylphthalimide 

Downstream Products

• 81087-58-3 5,7-Dimethyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-42-5 5,7-Dimethyl-2,4-dioxo-3-o-tolyl-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-59-4 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H,3H)-quinazolinedione 
• 81087-41-4 3-(2-Fluoro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 136743-76-5 2-(2-Chloro-phenylamino)-5,7-dimethyl-4-oxo-4H-benzo[d][1,3]oxazine-6-carboxylic acid ethyl ester 
• 81087-73-2 3-(2-Chloro-phenyl)-1,5,7-trimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 136743-90-3 1-(2-Aminoethyl)-3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione 
• 136743-91-4 1-(3-Amino-propyl)-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 136743-77-6 3-(2-Chlorophenyl)-1-(2-cyanoethyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione 
• 81087-67-4 1-carbamoylmethyl-3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione 
• 136743-94-7 1-Carboxymethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-74-3 3-(2-Chloro-phenyl)-1-(2-dimethylamino-ethyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-77-6 1-tert-Butoxycarbonylmethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-60-7 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-[3-(N,N-dimethylamino)propyl]-2,4-(1H,3H)-quinazolinedione 

Relevant academic research and scientific papers

Quinazolinde-dione compounds, process for production thereof and pharmaceutical use thereof

A 5,6,7-substituted-2,4(1H,3H)-quinazolinedione compound of the formula (I), STR1 wherein R1, R2, R3, A and B are as defined in claim 1 and its acid addition salt; and a vasodilating and hypotensive composition containing the aforesaid compound.

SYNTHESES OF 2-HYDROXYMETHYL-4(3H)-QUINAZOLINONE AND ITS ANALOGS

The syntheses of 6-ethoxycarbonyl-2-hydroxymethyl-5,7-dimethyl-4(3H)-quinazolinone, 7-(or 6-)-ethoxycarbonyl-2,6,8-(or 2,5,7-)-trimethyl-3-phenyl-4(3H)-quinazolinone were described.The 3-phenyl-4(3H)-quinazolinone compounds were further converted to the corresponding 2-hydroxymethyl derivative.The starting compounds, 2-amino-4-ethoxycarbonyl-3,5-dimethylbenzoic acid and 2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid were prepared by the Hofmann reaction of the corresponding phthalimide.