67467-27-0

Upstream product

• 77307-59-6 4-ethoxycarbonyl-3,5-dimethylphthalimide 
• 56611-62-2 3,5-dimethyl-4-ethoxycarbonyl-phthalic anhydride 

Downstream Products

• 75958-37-1 4-acetylamino-2,6-dimethyl-1,3-benzenedicarboxylic acid 1-ethyl ester 
• 81087-75-4 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-<2-(1-piperidinyl)ethyl>-2,4(1H,3H)-quinazolinedione 
• 136744-06-4 3-(2-Chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1-{2-[4-((E)-3-phenyl-allyl)-piperazin-1-yl]-ethyl}-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride 
• 136744-05-3 3-(2-Chloro-phenyl)-1-[2-(4-ethoxycarbonylmethyl-piperazin-1-yl)-ethyl]-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride 
• 136743-80-1 3-(2-Chloro-phenyl)-1-[2-(4-ethoxycarbonyl-piperazin-1-yl)-ethyl]-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride 
• 81088-25-7 3-(2-Chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1-(2-piperidin-1-yl-ethoxycarbonylmethyl)-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride 
• 81088-28-0 3-(2-Chloro-phenyl)-1-(3-dimethylamino-propoxycarbonylmethyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride 
• 81087-76-5 3-(2-Chloro-phenyl)-5,7-dimethyl-1-(2-morpholin-4-yl-ethyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride 
• 136766-15-9 3-(2-Chloro-phenyl)-1-(2-ethoxycarbonimidoyl-ethyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride 
• 136766-16-0 1-(2-Carbamimidoyl-ethyl)-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride 
• 136743-82-3 1-[2-(4-tert-Butoxycarbonylmethyl-piperazin-1-yl)-ethyl]-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 136743-89-0 3-(2-Chloro-phenyl)-1-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 136743-88-9 3-(2-Chloro-phenyl)-1-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 136743-87-8 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-(N-phthaloylamino)ethyl-2,4-(1H,3H)-quinazolinedione 

Relevant academic research and scientific papers

Quinazolinde-dione compounds, process for production thereof and pharmaceutical use thereof

A 5,6,7-substituted-2,4(1H,3H)-quinazolinedione compound of the formula (I), STR1 wherein R1, R2, R3, A and B are as defined in claim 1 and its acid addition salt; and a vasodilating and hypotensive composition containing the aforesaid compound.

SYNTHESES OF 2-HYDROXYMETHYL-4(3H)-QUINAZOLINONE AND ITS ANALOGS

The syntheses of 6-ethoxycarbonyl-2-hydroxymethyl-5,7-dimethyl-4(3H)-quinazolinone, 7-(or 6-)-ethoxycarbonyl-2,6,8-(or 2,5,7-)-trimethyl-3-phenyl-4(3H)-quinazolinone were described.The 3-phenyl-4(3H)-quinazolinone compounds were further converted to the corresponding 2-hydroxymethyl derivative.The starting compounds, 2-amino-4-ethoxycarbonyl-3,5-dimethylbenzoic acid and 2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid were prepared by the Hofmann reaction of the corresponding phthalimide.