67469-81-2 Usage
Uses
A very potent and selective inhibitor of dopamine uptake
Definition
ChEBI: A hydrochloride salt that is obtained by reaction of 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine with two equivalents of hydrogen chloride. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal memb
anes).
Biochem/physiol Actions
GBR 12935 inhibits the dopamine and norepinephrine transporters with Kis of 21.5 nM and 225 nM, respectively. It does not inhibit the serotonin transporter (Ki = 6.5 mM). GBR 12935 binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450.
Check Digit Verification of cas no
The CAS Registry Mumber 67469-81-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,4,6 and 9 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 67469-81:
(7*6)+(6*7)+(5*4)+(4*6)+(3*9)+(2*8)+(1*1)=172
172 % 10 = 2
So 67469-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C28H34N2O.ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;/h1-9,11-12,14-17,28H,10,13,18-24H2;1H
67469-81-2Relevant articles and documents
N-Benzhydryloxyethyl-N-phenylpropyl-piperazines
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, (2008/06/13)
Piperazine derivatives of the general formula STR1 wherein R1 -R9 are the same or different and each represents a hydrogen or halogen atom or a lower alkyl or lower alkoxy group, n is 2 or 3 and X represents a group (CH2)m (in which m is 1, 2, 3 or 4) or a group --CH2 --CH=CH--, having methylene linked to the piperazine group, and acid addition and quaternary ammonium salts thereof, are described. The compounds exhibit a strong specific dopaminergic activity. Also described are methods for their preparation and use as therapeutic agents in the form of therapeutic compositions.
