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6747-43-9

The chemical compound "2-{5-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-3-methyl-butyric acid" is a complex organic molecule with a molecular formula of C18H18N2O4S3. It features a thiazolidin-3-yl core, which is a heterocyclic ring system containing sulfur and nitrogen. The compound is characterized by a 4-dimethylamino-phenyl group attached to a meth-(Z)-ylidene moiety, which contributes to its conjugated system and electronic properties. The molecule also includes a 3-methyl-butyric acid side chain, which may influence its solubility and reactivity. 2-{5-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-3-methyl-butyric acid is likely to be of interest in the fields of medicinal chemistry and materials science due to its potential applications in drug development and the creation of novel materials.

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  • 6747-43-9 Structure

  • Basic information

    1. Product Name: 2-{5-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-3-methyl-butyric acid
    2. Synonyms:
    3. CAS NO:6747-43-9
    4. Molecular Formula:
    5. Molecular Weight: 364.489
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 6747-43-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-{5-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-3-methyl-butyric acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-{5-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-3-methyl-butyric acid(6747-43-9)
    11. EPA Substance Registry System: 2-{5-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-3-methyl-butyric acid(6747-43-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 6747-43-9(Hazardous Substances Data)

6747-43-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6747-43-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,7,4 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6747-43:
(6*6)+(5*7)+(4*4)+(3*7)+(2*4)+(1*3)=119
119 % 10 = 9
So 6747-43-9 is a valid CAS Registry Number.

6747-43-9Downstream Products

6747-43-9Relevant articles and documents

In Silico Driven Design and Synthesis of Rhodanine Derivatives as Novel Antibacterials Targeting the Enoyl Reductase InhA

Slepikas, Liudas,Chiriano, Gianpaolo,Perozzo, Remo,Tardy, Sébastien,Kranjc, Agata,Patthey-Vuadens, Ophélie,Ouertatani-Sakouhi, Hajer,Kicka, Sébastien,Harrison, Christopher F.,Scrignari, Tiziana,Perron, Karl,Hilbi, Hubert,Soldati, Thierry,Cosson, Pierre,Tarasevicius, Eduardas,Scapozza, Leonardo

, p. 10917 - 10928 (2016)

Here, we report on the design, synthesis, and biological evaluation of 4-thiazolidinone (rhodanine) derivatives targeting Mycobacterial tuberculosis (Mtb) trans-2-enoyl-acyl carrier protein reductase (InhA). Compounds having bulky aromatic substituents at position 5 and a tryptophan residue at position N-3 of the rhodanine ring were the most active against InhA, with IC50 values ranging from 2.7 to 30 μM. The experimental data showed consistent correlations with computational studies. Their antimicrobial activity was assessed against Mycobacterium marinum (Mm) (a model for Mtb), Pseudomonas aeruginosa (Pa), Legionella pneumophila (Lp), and Enterococcus faecalis (Ef) by using anti-infective, antivirulence, and antibiotic assays. Nineteen out of 34 compounds reduced Mm virulence at 10 μM. 33 exhibited promising antibiotic activity against Mm with a MIC of 0.21 μM and showed up to 89% reduction of Lp growth in an anti-infective assay at 30 μM. 32 showed high antibiotic activity against Ef, with a MIC of 0.57 μM.

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