674776-54-6

Basic information

• Product Name: 4-(P-TOLUENESULFONYLAMINO)PHENYLBORONIC ACID PINACOL ESTER, 97%
• Synonyms: 4-(p-Toluenesulfonylamino)phenylboronic acid pinacol ester, N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-p-toluenesulfonamide
• CAS NO: 674776-54-6
• Molecular Formula: C19H24BNO4S
• Molecular Weight: 373.27
• Mol File: 674776-54-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 502.401°C at 760 mmHg
• Flash Point: 257.643°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 4-(P-TOLUENESULFONYLAMINO)PHENYLBORONIC ACID PINACOL ESTER, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(P-TOLUENESULFONYLAMINO)PHENYLBORONIC ACID PINACOL ESTER, 97%(674776-54-6)
• EPA Substance Registry System: 4-(P-TOLUENESULFONYLAMINO)PHENYLBORONIC ACID PINACOL ESTER, 97%(674776-54-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 674776-54-6(Hazardous Substances Data)

Usage

General Description

4-(p-toluenesulfonylamino)phenylboronic acid pinacol ester is a chemical compound that is commonly used in organic synthesis. It is a boronic acid derivative that can be used in various reactions, including Suzuki-Miyaura coupling and other catalytic processes. This particular chemical is a high-purity 97% compound, making it suitable for use in research and industrial applications. The pinacol ester group in the molecule provides stability and facilitates the compound's reactivity in various reactions. Overall, it is a valuable reagent for organic chemists and researchers working in the field of chemical synthesis.

InChI:InChI=1/C19H24BNO4S/c1-14-6-12-17(13-7-14)26(22,23)21-16-10-8-15(9-11-16)20-24-18(2,3)19(4,5)25-20/h6-13,21H,1-5H3

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 73852-88-7 2-(4-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 98-59-9 p-toluenesulfonyl chloride 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 158268-30-5 N-tosyl-4-iodoaniline 
• 73183-34-3 bis(pinacol)diborane 

Relevant articles and documents

Au(i)/Au(iii)-Catalyzed C-N coupling

Cycling between Au(i) and Au(iii) is challenging, so gold-catalyzed cross-couplings are rare. The (MeDalphos)AuCl complex, which we showed was prone to undergo oxidative addition, is reported here to efficiently catalyze the C-N coupling of aryl iodides and amines. The transformation does not require an external oxidant or a directing group. It is robust and works with a wide scope of aryl iodides and N-nucleophiles under mild conditions. Mechanistic studies, including the NMR and MS characterization of a key aryl amido Au(iii) complex, strongly support a 2e redox cycle in which oxidative addition precedes transmetalation and reductive elimination is the rate-determining step.

2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

A 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented by the generalformula (1): [Chemical formula 1] (1) or a pharmaceutically acceptable saltthereof. They are useful as a therapeutic/preventive agent for diabetes, diabeticnephropathy, or glomerulosclerosis.