674779-52-3Relevant academic research and scientific papers
NOVEL AMINE DERIVATIVE OR SALT THEREOF
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Paragraph 0528-0529; 0611-0612, (2015/11/11)
A novel amine derivative expressed by general formula (1) (in the formula: G1, G2, and G3 are the same or different and represent CH or a nitrogen atom; R1 represents a chlorine atom, an optionally-substituted C3-8 cycloalkyl group, or the like; R2 represents -COOR5 (in the formula, R5 represents a hydrogen atom or a carboxyl protective group), or the like; R3 represents a hydrogen atom, or the like; and R4 represents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.
Direct cyanation of picolinamides using K4[Fe(CN)6] as the cyanide source
Guan, Dinghui,Han, Lu,Wang, Lulu,Song, He,Chu, Wenyi,Sun, Zhizhong
supporting information, p. 743 - 745 (2015/06/22)
The efficient, simple, and environment-friendly route of direct cyanation of picolinamides has been developed with nontoxic K4[Fe(CN)6] as the cyanide source through Pdcatalyzed C-H bond activation. A series of N-(naphthalene-1- yl)picolinamide derivatives were successfully transformed to the corresponding cyanation products. The cyanation mechanism has also been speculated.
