67478-46-0

Usage

Uses

Used in Organic Synthesis:
2-Iodo-1-trityl-1H-imidazole is utilized as a halogenating agent in organic synthesis, capitalizing on the reactivity of the iodo group to facilitate various chemical reactions. Its trityl group also contributes to the stability of the compound during these processes.
Used in Pharmaceutical and Biological Compounds Synthesis:
2-Iodo-1-trityl-1H-imidazole serves as a versatile reagent in the synthesis of a range of pharmaceutical and biological compounds, owing to its unique structural features and chemical properties that can be harnessed in the development of new drugs and therapies.
Used in Medicinal Chemistry and Drug Development:
2-Iodo-1-trityl-1H-imidazole is explored in medicinal chemistry for its potential to contribute to the discovery and design of novel drugs. Its unique structure and properties make it a promising candidate for further research and development in the creation of new therapeutic agents.

Upstream product

• 15469-97-3 N-tritylimidazole 

Relevant academic research and scientific papers

FRICTIONLESS MOLECULAR ROTARY MOTORS

A rotaxane consisting of a cucurbituril and an uncharged guest molecule, having low or null affinity therebetween is provided as well as processes for providing the same. Various uses as energy converters (“frictionless” molecular motors), biochips and biosensors using the same are also provided.

Palladium-catalyzed intramolecular arylation of N-benzyl-2-iodoimidazoles: A facile and rapid access to 5H-imidazo[2,1-α]isoindoles

The first example of a Pd-catalyzed intramolecular arylation involving the C-2 position of an imidazole ring is presented. Application of this reaction led to the formation of 5H-imidazo[2,1-a]isoindole in one step from N-benzyl-2-iodoimidazole. Microwave irradiation enhanced the rate of reaction allowing the synthesis of various imidazo[2,1-a]isoindole analogues. Georg Thieme Verlag Stuttgart.

Remarkable Selectivity in the Reaction of 1-Trityl-2-lithioimidazoles with t-Butyl Halogenoacetates

2-Lithio-1-triphenylmethylimidazoles react with t-butyl halogenoacetates to give a variety of products, the nature of which is cleanly determined by the halogen atom.With chloroacetate the products are chloromethyl ketones, while bromacetate gives di-t-butyl imidazolesuccinates, and iodoacetate yields iodoimidazoles.In each case 50percent of the parent triphenylmethylimidazole is recovered from the reaction.When the triphenylmethyl substituent is replaced by the N,N-dimethylsulfamoyl group, reaction with bromoacetate is suppressed, but t-butyl chloroacetate and iodoacetate again give chloroketones and aryl iodides respectively.