674781-60-3

Upstream product

• 108-98-5 thiophenol 
• 674781-59-0 (+)-methyl [(4aS,8R,8aS)-7-bromo-1,1,6-trimethyl-8-(4-methoxyphenylsulfonyl)-1,3,4,5,8,8a-hexahydronaphthalen-4a(2H)-yl]acetate 
• 674781-57-8 (+)-methyl [(4aS,8R,8aS)-7-bromo-1,1,6-trimethyl-8-(4-methoxyphenylsulfanyl)-1,3,4,5,8,8a-hexahydronaphthalen-4a(2H)-yl]acetate 
• 674781-44-3 (-)-methyl [(1aR,1bS,5aS,6aS)-1,1-dibromo-2,2,6a-trimethyloctahydrocyclopropa[a]inden-5a-(1H)-yl]acetate 
• 674781-43-2 (1S)-(2,2-dimethyl-6-methylenecyclohexyl)-2-methylprop-2-enyl methyl carbonate 
• 674781-56-7 (-)-methyl [(3aS,7aS)-2,7,7-trimethyl-3,4,5,6,7,7a-hexahydro-3aH-inden-3a-yl]acetate 
• 674781-41-0 (-)-[(3aS,7aS)-2,7,7-trimethyl-3,4,5,6,7,7a-hexahydro-3aH-inden-3a-yl]acetic acid 
• 166022-22-6 (1S)-(+)-2,2-dimethyl-6-methylene-1-cyclohexanecarboxylic acid 
• 166022-29-3 (S)-(+)-(2',2'-dimethyl-6'-methylene-1'-cyclohexyl)methanol 
• 166022-30-6 (S)-(+)-2',2'-dimethyl-6'-methylene-1'-cyclohexylcarboxaldehyde 

Downstream Products

• 674781-50-1 (-)-(1S,6S,9S)-8-phenylthio-5,5,9-trimethyltricyclo[7.2.1.0^1,6]dodec-7-en-10-one 
• 674781-49-8 (+)-phenylselenyl [(4aS,8R,8aS)-7-phenylthio-1,1,6-trimethyl-8-(4-methoxyphenylsulfonyl)-1,3,4,5,8,8a-hexahydronaphthalen-4a(2H)-yl]acetate 

Relevant academic research and scientific papers

Total Synthesis of (+)-Acanthodoral by the Use of a Pd-Catalyzed Metal-ene Reaction and a Nonreductive 5-exo-Acyl Radical Cyclization

(Equation presented) The first total synthesis of the antibiotic acanthodoral (1) has been achieved from 3-methyl-2-cyclohexen-1-one in 19 steps in 2.1% overall yield. The synthesis features the use of a Pd-ene reaction in the presence of CO to form the endocyclic alkene 8, a nonreductive acyl radical cyclization reaction, and a ring contraction reaction by the Wolff rearrangement. (+)-Acanthodoral has also been synthesized starting from (+)-S-2,2-dimethyl-6-methylenecyclohexanecarboxylic acid.