674785-55-8

Basic information

• Product Name: 2-Hexen-1-one, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,3-diphenyl-, (2E)-
• CAS NO: 674785-55-8
• Molecular Formula: C24H32O2Si
• Molecular Weight: 380.602
• Mol File: 674785-55-8.mol

Chemical Properties

• CAS DataBase Reference: 2-Hexen-1-one, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,3-diphenyl-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hexen-1-one, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,3-diphenyl-, (2E)-(674785-55-8)
• EPA Substance Registry System: 2-Hexen-1-one, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,3-diphenyl-, (2E)-(674785-55-8)

Safety Data

• Hazardous Substances Data: 674785-55-8(Hazardous Substances Data)

Upstream product

• 61362-77-4 5-[tert-butyldimethylsilyloxy]pent-1-yne 
• 476445-30-4 6-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-hex-2-yn-1-one 
• 591-51-5 phenyllithium 

Relevant articles and documents

MITOTIC KINESIN INHIBITORS

The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

Two-step synthesis of β-alkyl chalcones and their use in the synthesis of 3,5-diaryl-5-alkyl-4,5-dihydropyrazoles

We report a simple and efficient two-step synthesis of variously substituted β-alkyl chalcones (7) from the corresponding Weinreb amide and a terminal alkyne, and that these chalcones are useful intermediates for the synthesis of medicinally interesting 3,5-diaryl-5-alkyl-4,5-dihydropyrazoles (6). The current methodology allows for the incorporation of many substitution patterns not available from the few previously reported approaches to compounds in this class.