674786-93-7Relevant academic research and scientific papers
Asymmetric synthesis of spiro 2-pyrrolidin-5-ones, 2-piperidin-6-ones and 1-isoindolin-3-ones. Part 2: N-Acyliminium ion cyclisations with an internal alkene nucleophile
Bahajaj, Abood A.,Vernon, John M.,Wilson, Giles D.
, p. 1247 - 1253 (2004)
Chiral non-racemic bicyclic and tricyclic oxylactams obtained in two steps from N-(2-hydroxy-1(R)-phenylethyl)-succinimide and phthalimide are cyclised diastereoselectively in formic acid to give spiro[cyclohexane-1,2′- pyrrolidin]-5-ones and spiro[cyclohexane-1,1′-isoindolin]-3-ones, respectively.
A novel asymmetric azaspirocyclisation using a Morita-Baylis-Hillman-type reaction
Killen, Jonathan C.,Leonard, John,Aggarwal, Varinder K.
supporting information; experimental part, p. 579 - 582 (2010/10/02)
A Morita-Baylis-Hillman-type reaction has been applied to the asymmetric preparation of azaspirocycles in high yield and diastereoselectivity. The optimisation of the reaction is discussed and a model for the origin of diastereoselectivity is proposed. Georg Thieme Verlag Stuttgart.
