674792-00-8

Basic information

• Product Name: 1-Piperazinecarboxylic acid, 2-(2-methylpropyl)-4-(phenylmethyl)-, 1,1-dimethylethyl ester, (2S)-
• CAS NO: 674792-00-8
• Molecular Formula: C20H32N2O2
• Molecular Weight: 332.486
• Mol File: 674792-00-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Piperazinecarboxylic acid, 2-(2-methylpropyl)-4-(phenylmethyl)-, 1,1-dimethylethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxylic acid, 2-(2-methylpropyl)-4-(phenylmethyl)-, 1,1-dimethylethyl ester, (2S)-(674792-00-8)
• EPA Substance Registry System: 1-Piperazinecarboxylic acid, 2-(2-methylpropyl)-4-(phenylmethyl)-, 1,1-dimethylethyl ester, (2S)-(674792-00-8)

Safety Data

• Hazardous Substances Data: 674792-00-8(Hazardous Substances Data)

Upstream product

• 444892-03-9 (3S)-1-benzyl-3-isobutylpiperazine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 502482-25-9 (3S)-1-benzyl-3-isobutylpiperazine-2,5-dione 
• 2666-93-5 (S)-Leu-OMe 
• 1223471-36-0 C₂₀H₃₀N₂O₃ 

Relevant articles and documents

Structure-Activity Relationship Studies on Oxazolo[3,4- a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent in Vivo Activity

Neuropeptide S modulates important neurobiological functions including locomotion, anxiety, and drug abuse through interaction with its G protein-coupled receptor known as neuropeptide S receptor (NPSR). NPSR antagonists are potentially useful for the treatment of substance abuse disorders against which there is an urgent need for new effective therapeutic approaches. Potent NPSR antagonists in vitro have been discovered which, however, require further optimization of their in vivo pharmacological profile. This work describes a new series of NPSR antagonists of the oxazolo[3,4-a]pyrazine class. The guanidine derivative 16 exhibited nanomolar activity in vitro and 5-fold improved potency in vivo compared to SHA-68, a reference pharmacological tool in this field. Compound 16 can be considered a new tool for research studies on the translational potential of the NPSergic system. An in-depth molecular modeling investigation was also performed to gain new insights into the observed structure-activity relationships and provide an updated model of ligand/NPSR interactions.

PIPERAZINE UREA DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS

Certain novel piperazine urea derivatives are agonists of the human melanocortin-4 receptor (MC-4R) and, in particular, are receptor-subtype selective agonists of MC-4R. They are useful for the treatment, control, or prevention of diseases and disorders r