674806-65-6

Basic information

• Product Name: 8-amino-2-anilino-6-(4-bromophenyl)-5-oxo-4,6-dihydro-5H-pyrano[2,3-d][1,3]thiazolo[4,5-b]pyridine-7-carbonitrile
• Synonyms: 8-amino-2-anilino-6-(4-bromophenyl)-5-oxo-4,6-dihydro-5H-pyrano[2,3-d][1,3]thiazolo[4,5-b]pyridine-7-carbonitrile
• CAS NO: 674806-65-6
• Molecular Formula: C₂₂H₁₄BrN₅O₂S
• Molecular Weight: 492.34786
• Mol File: 674806-65-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-amino-2-anilino-6-(4-bromophenyl)-5-oxo-4,6-dihydro-5H-pyrano[2,3-d][1,3]thiazolo[4,5-b]pyridine-7-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 8-amino-2-anilino-6-(4-bromophenyl)-5-oxo-4,6-dihydro-5H-pyrano[2,3-d][1,3]thiazolo[4,5-b]pyridine-7-carbonitrile(674806-65-6)
• EPA Substance Registry System: 8-amino-2-anilino-6-(4-bromophenyl)-5-oxo-4,6-dihydro-5H-pyrano[2,3-d][1,3]thiazolo[4,5-b]pyridine-7-carbonitrile(674806-65-6)

Safety Data

• Hazardous Substances Data: 674806-65-6(Hazardous Substances Data)

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 70604-16-9 7-hydroxy-2-(phenylamino)[1,3]thiazolo[4,5-b]pyridin-5(4H)-one 
• 109-77-3 malononitrile 

Relevant articles and documents

Synthesis of substituted thiazolo[4,5-b]pyridines and other annulated heterocycles via SN2→Thorpe-Ziegler→Thorpe-Guareschi domino reactions

A new combinatorial method for the preparation of substituted thiazolo[4,5-b]pyridines, which utilizes cyanoacetamide, heterocumulenes (isothiocyanates, carbon bisulfide), and ethyl-4-chloroacetoacetate in a new SN2→Thorpe-Ziegler→Thorpe-Guareschi domino reactions has been developed. The obtained thiazolo[4,5-b]pyridines were then used together with aldehydes and malononitrile in another Knoevenagel reaction→Michael reaction→hetero-Thorpe-Ziegler domino reaction for the synthesis of substituted 4,6-dihydro-5H-pyrano[2,3-d]thiazolo[4,5-b]pyridines.