674810-59-4

Upstream product

• 674810-55-0 ethyl (E)-N-benzyloxycarbonyl-2,3,4,7-tetradeoxy-4,7-imino-5,6-O-isopropylidene-L-ribo-hept-2-enonate 
• 117859-46-8 1,4-Dideoxy-2,3:5,6-di-O-isopropylidene-1,4-imino-D-allitol 
• 501-53-1 benzyl chloroformate 
• 405215-53-4 N-benzyloxycarbonyl-2,5-dideoxy-2,5-imino-3,4-O-isopropylidene-L-ribose 
• 405283-44-5 N-(benzyloxycarbonyl)-1,4-dideoxy-1,4-imino-2,3:5,6-di-O-isopropylidene-D-allitol 
• 405283-43-4 N-benzyloxycarbonyl-1,4-dideoxy-1,4-imino-2,3-O-isopropylidene-D-allitol 

Relevant academic research and scientific papers

Stereoselective synthesis of novel tetrahydroxypyrrolizidines

N-Benzyloxycarbonyl-2,5-dideoxy-2,5-imino-3,4-O-isopropylidene-L-ribose 12a has been converted into (1R,2S,6R,7S,7aS)-5 and (1R,2S,6S,7R,7aR)-1,2,6,7- tetrahydroxypyrrolidin-5-ones 6 and (1R,2S,6S,7S,7aS)-7 and (1R,2S,6R,7R,7aS)-1, 2,6,7-tetrahydroxypyrrolizidines 8 following stereoselective paths. These new compounds have been assayed for their inhibitory activities towards 25 glycosidases. Pyrrolizidines 7 and 8 are moderate but selective inhibitors of amyloglucosidase from Rhizopus mold (7: IC50=130μM, K i=120μM; 8: IC50=200μM, Ki=180μM, mixed type of inhibition).