67487-35-8

Usage

Chemical Properties

off-white powder or chunks

InChI:InChI=1/C7H6Cl2N2O/c8-4-1-2-6(9)5(3-4)7(12)11-10/h1-3H,10H2,(H,11,12)

Upstream product

• 35112-27-7 ethyl 2,5-dichlorobenzoate 
• 2905-69-3 methyl 2,5-dichlorobenzoate 
• 2905-61-5 2,5-dichlorobenzoyl chloride 

Downstream Products

• 124595-15-9 2,5-dichloro-N'-(5-nitrofurfurylidene)benzohydrazide 
• 113398-17-7 [5-(2,5-Dichloro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-carbamic acid benzyl ester 
• 139397-78-7 [(2,5-Dichloro-benzoyl)-hydrazono]-acetic acid 
• 23269-73-0 5-(2,5-dichloro-phenyl)-[1,3,4]oxadiazole-2-thiol 
• 139397-55-0 (2S,5R,6R)-6-(2-{2-[(2,5-Dichloro-benzoyl)-hydrazono]-acetylamino}-2-phenyl-acetylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 
• 676349-90-9 2,5-Dichloro-N'-[(9,9-dioctyl-9H-fluoren-2-yl)carbonyl]benzohydrazide 
• 1219921-81-9 C₁₂H₁₂Cl₂N₂O₄ 
• 68496-90-2 5-(2,5-dichloro-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester 
• 1333376-19-4 C₁₇H₁₃Cl₂N₃O₂ 
• 68497-01-8 1-Ethoxalyl-2-(2,5-dichlorbenzoyl)-hydrazin 
• 1430092-69-5 C₁₄H₈Cl₂N₂O₂S 
• 1616086-44-2 2-(2,5-dichlorophenyl)-5-methyl-1,3,4-oxadiazole 
• 23289-01-2 2-(2,5-dichlorophenyl)-1,3,4-oxadiazole 
• 1417411-04-1 8-bromo-1-(2,5-dichlorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline 

Relevant academic research and scientific papers

Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists

Relaxin family peptide receptors (RXFPs) are the potential therapeutic targets for neurological, cardiovascular, and metabolic indications. Among them, RXFP3 and RXFP4 (formerly known as GPR100 or GPCR142) are homologous class A G protein-coupled receptors with short N-terminal domain. Ligands of RXFP3 or RXFP4 are only limited to endogenous peptides and their analogues, and no natural product or synthetic agonists have been reported to date except for a scaffold of indole-containing derivatives as dual agonists of RXFP3 and RXFP4. In this study, a new scaffold of tricyclic derivatives represented by compound 7a was disclosed as a selective RXFP4 agonist after a high-throughput screening campaign against a diverse library of 52,000 synthetic and natural compounds. Two rounds of structural modification around this scaffold were performed focusing on three parts: 2-chlorophenyl group, 4-hydroxylphenyl group and its skeleton including cyclohexane-1,3-dione and 1,2,4-triazole group. Compound 14b with a new skeleton of 7,9-dihydro-4H-thiopyrano[3,4-d][1,2,4]triazolo[1,5-a]pyrimidin-8(5H)-one was thus obtained. The enantiomers of 7a and 14b were also resolved with their 9-(S)-conformer favoring RXFP4 agonism. Compared with 7a, compound 9-(S)-14b exhibited 2.3-fold higher efficacy and better selectivity for RXFP4 (selective ratio of RXFP4 vs. RXFP3 for 9-(S)-14b and 7a were 26.9 and 13.9, respectively).

Potent oxadiazole CGRP receptor antagonists for the potential treatment of migraine

A pharmacophore model was built, based on known CGRP receptor antagonists, and this was used to aid the identification of novel leads. Analogues were designed, modelled and synthesised which incorporated alternative 'LHS' fragments linked via either an amide or urea to a privileged 'RHS' fragment commonly found in CGRP receptor antagonists. As a result a novel series of oxadiazole CGRP receptor antagonists has been identified and the subsequent optimisation to enhance both potency and bioavailability is presented.

Electron transport agents for organic electronic devices

Compounds and compositions are provided that can be used as electron transport agents in organic electronic devices such as organic electroluminescent devices. The compounds are non-polymeric and have an aromatic core conjugated to end capping groups. The aromatic core contains a phenylene group arylene or naphthalene group arylene having a pendant heteroaryl group that includes a —C═N— unit.

Electroactive polymers

Electroactive polymeric arylenes and intermediates useful for making such polymers are disclosed. The present invention also provides electroactive compositions comprising the electroactive polymeric arylenes, organic electronic devices which comprise these polymers and compositions, and methods of fabricating these devices.

Stereoselective synthesis and fungicidal activities of (E)-α- (methoxyimino)-benzeneacetate derivatives containing 1,3,4-oxadiazole ring

Fifteen novel (E)-α-(methoxyimino)-benzeneacetate derivatives, the analogues of strobilurins, which contain two pharmacophoric substructures of (E)-methyl methoxyiminoacetate moiety and 1,3,4-oxadiazole ring were stereoselectively synthesized. It was first found that the coupling reaction could give stereoselectively the key intermediate (E) and (Z)-methyl 2-(hydroxyimino)-2-o-tolylacetate 2 with a ratio of 14:1. The preliminary bioassays indicated that all the compounds 1 showed potent fungicidal activity against Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Physalospora piricola and Bipolaris mayclis, and all of the tested compounds 1a-1o had more potent fungicidal activities against R. solani than Kresoxim-methyl.