67491-43-4Relevant articles and documents
One-step synthesis of 4,4′-dicyano-2,2′-bipyridine and its bis(4,4′-di-tert-butyl-2,2′-bipyridine)ruthenium(II) complex
Losse, Sebastian,Goerls, Helmar,Groarke, Robert,Vos, Johannes G.,Rau, Sven
, p. 4448 - 4452 (2008)
This report describes a new route for the fast, economical and effective one-step synthesis and facile workup procedure of 4,4′-dicyano-2,2′- bipyridine (dnbpy) and its corresponding ruthenium complexes. The complex [(tbbpy)2Ru(dnbpy)]-PF6)2 was prepared for the first time (tbbpy = 4,4′-di-tert-butyl-2,2′-bipyridine) and the solid-state molecular structure was investigated with the help of a single-crystal X-ray analysis. The influence of the dnbpy ligand on the metal-to-ligand charge-transfer (MLCT) processes of the complex was studied. The compound shows two absorption maxima in the MLCT region of the UV/Vis spectrum at 418 and 510 nm and the emission is 116 nm redshifted in comparison to that of [(tbbpy)3Ru](PF6)2. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
A Systematic Study of the Effects of Complex Structure on Aryl Iodide Oxidative Addition at Bipyridyl-Ligated Gold(I) Centers
Bower, John F.,Cadge, Jamie A.,Russell, Christopher A.
supporting information, p. 24976 - 24983 (2021/10/20)
A combined theoretical and experimental approach has been used to study the unusual mechanism of oxidative addition of aryl iodides to [bipyAu(C2H4)]+ complexes. The modular nature of this system allowed a systematic assessment of the effects of complex structure. Computational comparisons between cationic gold and the isolobal (neutral) Pd0 and Pt0 complexes revealed similar mechanistic features, but with oxidative addition being significantly favored for the group 10 metals. Further differences between Au and Pd were seen in experimental studies: studying reaction rates as a function of electronic and steric properties showed that ligands bearing more electron-poor functionality increase the rate of oxidative addition; in a complementary way, electron-rich aryl iodides give faster rates. This divergence in mechanism compared to Pd suggests that Ar?X oxidative addition with Au can underpin a broad range of new or complementary transformations.
S-adenosylmethionine decarboxylase inhibitors: New aryl and heteroaryl analogues of methylglyoxal bis(guanylhydrazone)
Stanek,Caravatti,Capraro,Furet,Mett,Schneider,Regenass
, p. 46 - 54 (2007/10/02)
A series of 3-acylbenzamidine (amidino)hydrazones 7a-h, the corresponding (hetero)aromatic congeners 7i-p, and 3,3'-bis-amidino-biaryls 25a-e were synthesized. The hydrazones 7a-p were prepared by conversion of the corresponding acyl nitriles 1a,c-d,i,n-p to the imido esters 3a,c-d,i and the amidines 5a,c-d,h-i, followed by a reaction with aminoguanidine, or vice versa. Similarly, the biaryl 3,3'-dinitriles 23a-e were converted, via the imino esters 24a-c or the imino thioesters 27d-e, to the diamidines 25a-e. These new products are conformationally constrained analogues of methylglyoxal bis(guanylhydrazone) (MGBG). They are up to 100 times more potent as inhibitors of rat liver S-adenosylmethionine decarboxylase (SAMDC) and generally less potent inhibitors of rat small intestine diamine oxidase (DAO) than MGBG. Some of these SAMDC inhibitors, e.g., compounds 7a, 7e, 7i, 25a, and 25d, have shown antiproliferative effects against T24 human bladder carcinoma cells. These products, whose structure-activity relationships are discussed, are of interest as potential anticancer agents and drugs for the treatment of protozoal and Pneumocystis carinii infections.
