67496-23-5

Upstream product

• 142749-19-7 (R)-2-((S)-2-Hydroxy-2-phenyl-ethyl)-pyrrolidin-1-ol 
• 67496-25-7 2(β)-phenylhexahydropyrrolo(1,2-b)isoxazole 

Downstream Products

• 70625-17-1 6-(2-hydroxy-2-phenyl-ethyl)-hexahydro-pyrrolo[1,2-b]isoxazole-2-carboxylic acid methyl ester 
• 142749-19-7 (R)-2-((S)-2-Hydroxy-2-phenyl-ethyl)-pyrrolidin-1-ol 

Relevant academic research and scientific papers

Cycloaddition of 5-substituted 1-pyrroline 1-oxide and conversion of the nitrone cycloadducts into cis- and trans-2,5-disubstituted pyrrolidines

A study of the regiochemical behaviour of the oxidation of 2-substituted-1-hydroxypyrrolidines (2) leading to aldo- and kit-nitrones has been carried out. The mechanism of the peracid induced ring opening reaction of isoxazolidines (5) is now firmly estab

Nitrone Cycloaddition: Peracid Oxidation of Perhydro-1,2-oxazolooxazines

Regiochemistry of peracid induced ring opening of perhydro-1,2-oxazolooxazines (2) and (6) in aprotic solvent is dictated by orientation of lone pair of electrons on nitrogen.In contrast to the case with the corresponding hexahydro-2H-isoxazol

Peracid Induced Ring Opening of Isoxazolidines. A Mechanistic Study.

Conformational analysis and mechanistic study of peracid induced ring opening of several isoxazolidines have been carried out.The orientation of the nitrogen lone pair dictates the regiochemistry of the ring opening which involves an intramolecular kinetic deprotonation of a nitroxonium ion intermediate.