67499-48-3

Upstream product

• 610-81-1 4-hydroxy-2-nitroaniline 
• 6315-52-2 1,2-bis-tosyloxyethane 

Downstream Products

• 1402085-19-1 1,2-bis[2-(4'-fluorophenyl)-1H-benzimidazole-5-yl-oxy]ethane 
• 1402085-04-4 1,2-bis[2-(4'-methoxyphenyl)-1H-benzimidazole-5-yl-oxy]ethane 
• 1402085-06-6 1,2-bis[2-(3',5'-methoxyphenyl)-1H-benzimidazole-5-yl-oxy]ethane 
• 1402085-08-8 1,2-bis[2-(3',4',5'-methoxyphenyl)-1H-benzimidazole-5-yl-oxy]ethane 
• 1402085-10-2 1,2-bis[2-(3'-methoxy-4'-hydroxyphenyl)-1H-benzimidazole-5-yl-oxy]ethane 
• 1402085-12-4 1,2-bis(2-phenyl-1H-benzimidazole-5-yl-oxy)ethane 
• 1402085-14-6 1,2-bis[2-(4'-bromophenyl)-1H-benzimidazole-5-yl-oxy]ethane 

Relevant academic research and scientific papers

Synthesis of quinoxaline cavitand baskets

The unique temperature, solvent and pH drivenvase?to?kite?equilibrium in quinoxaline cavitands allows the reversible uptake and release of guests. However, the cavity breathing associated with this conformational switch reduces the strength of complexatio

A new series of bisbenzimidazole derivatives: Synthesis, antitumor activity and low toxicity on PBMC

Herein, a new series of bisbenzimidazole derivatives were designed and synthesized. Most of these new compounds showed significant in vitro anticancer activity when compared to Hoechst 33258 and 5-FU. Among them, the most potent compound 8 had the IC50 values of 0.78 μM for U937 tumor cell line, 5.62 μM for HL60 tumor cell line and 6.97 μM for Hela tumor cell line. Molecular modeling, fluorescence and viscosimetry study showed that compound 8 could bind into the minor groove of DNA. Subsequent toxicity study on human peripheral blood mononuclear cells (PBMC), shows that compound 8 exhibited less toxicity than paclitaxel and 5-FU.