67502-20-9

Downstream Products

• 91504-11-9 {(2R,3S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopropyl-ethyl]-3-[1-(2-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-hydroxy-acetic acid 2-nitro-benzyl ester 

Relevant academic research and scientific papers

Process for preparing 1-6-and 2-substituted-1-carba-2-penem-3-carboxylic acids

Disclosed are 1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids of the following structure: STR1 wherein R1, R2, R3 and R4 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl, and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

Thienamycin derivatives

Disclosed is a process for the total synthesis of thienamycin from descysteaminylthinamycin 1 STR1 via thienamycin sulfoxide 4: STR2 R3, R°, R' are blocking groups.

1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids

Disclosed are 1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids of the following structure: STR1 wherein R1, R2, R3 and R4 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl, and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

6- and 1-Substituted-1-carbadethiapen-2-em-3-carboxylic acid

Disclosed are 6- and 1-substituted-1-carbadethiapen-2-em-3-carboxylic acids of the following structure: STR1 wherein R1, R2 and R3 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl, and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotics effect is indicated.