67502-95-8Relevant academic research and scientific papers
Structural assignment of 2,3,7,8-tetrahydro-5H,10H- [1,5,3]dioxazepino[3,2-c]indolo[3,2-g]pteridin-7-one, a new heterocyclic ring system
Ge,Kalman
, p. 257 - 260 (1998)
The structure of a new heterocyclic ring system, 2,3,7,8-tetrahydro- 5H,10H-[1,5,3]dioxazepino[3,2-c]-indolo[3,2-g]pteridin-7-one, derived from isatins and 5-aminocytidine was assigned by establishing the regiochemistry with the aid of model reactions and
One-pot solvent free, green route to novel substituted spiro[oxindole-isoxazolidine] derivatives: novel candidates as antimicrobial agents
KAUR, MANPREET,BHATIA, SUMEET KAUR,SINGH, BALDEV
, p. 1299 - 1303 (2021/06/09)
The environmentally benign catalyst and solvent-free synthesis of ketonitrones may not always be accomplished by simple condensation reactions. The occasional reports of green synthetic routes toward these compounds have been reported. The key features of
Stereocontrolled [3+2] Cycloaddition of Donor-Acceptor Cyclopropanes to Iminooxindoles: Access to Spiro[oxindole-3,2′-pyrrolidines]
Akaev, Andrey A.,Bezzubov, Stanislav I.,Desyatkin, Victor G.,Vorobyeva, Nataliya S.,Majouga, Alexander G.,Melnikov, Mikhail Ya.,Budynina, Ekaterina M.
, p. 3340 - 3356 (2019/03/11)
A novel stereocontrolled assembly of spiro[oxindole-3,2′-pyrrolidines] via [3+2]-cycloaddition of donor-acceptor cyclopropanes to electron-poor ketimines, iminooxindoles, was developed. The method allows for efficient employment of common readily available donor-acceptor cyclopropanes, functionalized with ester, keto, nitro, cyano etc. groups, and N-unprotected iminooxindoles. The stereospecificity of the initial SN2-like imine attack on a cyclopropane molecule together with a high diastereoselectivity of further C-C bond formation facilitate a rapid access to spiro[oxindole-3,2′-pyrrolidines] in their optically active forms. Preliminary in vitro testing of the synthesized compounds against LNCaP (p53+) and PC-3 (p53-) cells revealed good antiproliferative activities and p53-selectivity indices for several compounds that are intriguing in terms of their further investigation as inhibitors of MDM2-p53 interaction.
"On water" synthesis of spiro-indoles via Schiff bases
Panda, Siva S.,Jain, Subhash C.
experimental part, p. 1187 - 1194 (2012/09/25)
A fast, efficient, and clean "on water" synthesis of new Schiff bases and their conversion to spiro compounds under microwave irradiation, as well as in water, is reported. Indol-2,3-diones were reacted separately with various heterocyclic and aromatic am
Studies in spiroheterocycles: Part XI - Synthesis of novel fluorine containing 4',5'-dihydrospirothiadiazepine>-2(1H),5'-diones from isatins
Joshi, Krishna C.,Dandia, Anshu,Ahmed, Nidhal
, p. 639 - 641 (2007/10/02)
Reaction of mercaptoacetic acid with fluorinated 3-aryliminoindol-2-ones, prepared in situ from fluorinated indole-2,3-diones(isatins) and fluorinated anilines, yields 3'-arylspiro-2(1H),4'-diones(I).Under similar conditions, 3-(4-phenylpyrazol-5-ylimino)indol-2-ones(II) yield a novel system 4',5'-dihydro-9'-phenylspirothiadiazepine>-2(1H),5'-dione (III). 3-(4-Phenylpyrazol-5-ylimino)indol-2-ones have been synthesized by the reaction of fluorine containing indole-2,3-diones with 3-amino-4-phenylpyrazole in abs. ethanol.The structures of the compounds have been established on the basis of elemental analyses, and IR, PMR, 19F NMR and mass spectral data.
Spiro Heterocycles. Part-VII. Synthesis and Antibacterial Activity of some Fluorine containing Spiroindole>-2',4(1'H)-diones
Joshi, Krishna, C.,Jain, Renuka,Sharma, Vandana
, p. 430 - 431 (2007/10/02)
Several new fluorine containing spiroindole>-2',4(1'H)-diones have been synthesised by the condensation of chloroacetylchloride with Schiff bases of indole-2,3-diones.The structures are supported by analysis, ir and nmr spectra, and so
STUDIES IN SPIROHETEROCYCLES: PART IX : A NEW ELEGANT SYNTHESIS AND REACTIONS OF SOME NOVEL FLUORINE-CONTAINING SPIRO-2,4'(1H)-DIONES
Joshi, Krishna C.,Dandia, Anshu,Ahmed, Nidhal
, p. 2479 - 2485 (2007/10/02)
A number of novel fluorine-containing spiro-2,4'(1H)-diones have been synthetized by an elegant one-step procedure involving the condensation of fluorine-containing indole-2,3-diones, fluorinated aromatic amines and 3-mercaptopropanoic acid without isolating the intermediate isatin-3-anils.The spiro compounds have been further subjected to acetylation, chloroacetylation and Mannich reactions.N-Acetylated spiro compound was simultaneously synthetized from 1-acetylindole-2,3-dione and aniline.The structures of all the compounds have been confirmed on the basic of elemental analyses, ir, 1H nmr, 13C nmr, 19F nmr and mass spectral studies.
