675105-46-1

Basic information

• Product Name: 7-Oxa-1-azaspiro[4.4]non-1-en-6-one,1-oxide(9CI)
• Synonyms: 7-Oxa-1-azaspiro[4.4]non-1-en-6-one,1-oxide(9CI)
• CAS NO: 675105-46-1
• Molecular Formula: C7H9NO3
• Molecular Weight: 155.15
• Product Categories: GLYCINESCAFFOLD
• Mol File: 675105-46-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Oxa-1-azaspiro[4.4]non-1-en-6-one,1-oxide(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Oxa-1-azaspiro[4.4]non-1-en-6-one,1-oxide(9CI)(675105-46-1)
• EPA Substance Registry System: 7-Oxa-1-azaspiro[4.4]non-1-en-6-one,1-oxide(9CI)(675105-46-1)

Safety Data

• Hazardous Substances Data: 675105-46-1(Hazardous Substances Data)

Upstream product

• 1018670-73-9 7-oxa-1-azaspiro[4.4]nonan-6-one 

Relevant articles and documents

Synthesis and spin-trapping properties of a new spirolactonyl nitrone

(Chemical Equation Presented) Spin trapping using electron paramagnetic resonance (EPR) spectroscopy is commonly employed for the identification of transient radicals in chemical and biological systems. A spirolactonyl-nitrone with rigid H-bond acceptor, 7-oxa-1-azaspiro[4.4]non-1-en-6-one 1-oxide, CPCOMPO, has been synthesized and characterized, and its spin-trapping properties were investigated. The rate of formation of CPCOMPO-O2H was determined using competition kinetics between the superoxide/hydroperoxyl radical (O2?-/HO2?) trapping by CPCOMPO and the spontaneous dismutation of this radical in aqueous media. The rate constant of 60 M-1·s-1 is the highest rate constant thus far observed at neutral pH for any nitrones using the kinetic method employed. Decay kinetics were also experimentally investigated for CPCOMPO-O2H. The effect of rigid H-bond acceptor on the stability of the CPCOMPO-O2H were computationally rationalized and compared to that of EMPO-O2H, which has flexible H-bond acceptor, and results show the need of a "loose" H-bond acceptor for improved adduct stability.