675109-72-5

Basic information

• Product Name: Pyrazinecarboxylic acid, 6-[3-(5-methyl-3-phenyl-4-isoxazolyl)-5H-1,2,4-triazolo[3,4-a]isoindol-8- yl]-
• CAS NO: 675109-72-5
• Molecular Formula: C24H16N6O3
• Molecular Weight: 436.429
• Mol File: 675109-72-5.mol

Chemical Properties

• CAS DataBase Reference: Pyrazinecarboxylic acid, 6-[3-(5-methyl-3-phenyl-4-isoxazolyl)-5H-1,2,4-triazolo[3,4-a]isoindol-8- yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazinecarboxylic acid, 6-[3-(5-methyl-3-phenyl-4-isoxazolyl)-5H-1,2,4-triazolo[3,4-a]isoindol-8- yl]-(675109-72-5)
• EPA Substance Registry System: Pyrazinecarboxylic acid, 6-[3-(5-methyl-3-phenyl-4-isoxazolyl)-5H-1,2,4-triazolo[3,4-a]isoindol-8- yl]-(675109-72-5)

Safety Data

• Hazardous Substances Data: 675109-72-5(Hazardous Substances Data)

Upstream product

• 675109-29-2 (6-bromo-3H-isoindol-1-yl)hydrazine 
• 675108-96-0 8-bromo-3-(5-methyl-3-phenylisoxazol-4-yl)-5H-[1,2,4]triazolo[3,4-a]isoindole 
• 675109-55-4 8-(5,5-Dimethyl-[1,3,2]dioxaborinan-2-yl)-3-(5-methyl-3-phenylisoxazol-4-yl)-5H-[1,2,4]triazolo[3,4-a]isoindole 
• 23611-75-8 6-chloro-pyrazine-2-carboxylic acid methyl ester 

Relevant articles and documents

Cognition enhancing derivatives of isoxazole triazoloindane GABA-A alpha 5 receptor subunit ligands

The present invention relates to compounds of formula I: in which R1 is a linear group or a five membered heterocycle optionally fused to a phenyl ring, R2 is a 5-membered heterocycle, R3 is chosen from a range of substituents, m is 0-3 and n is 0 or 1; the compounds are generally inverse agonists at GABA-A receptors containing the alpha 5 subunit and so are useful in methods of enhancing cognition in subjects with diminished cognition in diseases such as Alzheimer's Disease.