675124-87-5Relevant academic research and scientific papers
Fine-Tuned Aminal Cleavage: A Concise Route to Differentially Protected Enantiopure syn-α,β-Diamino Esters
Viso, Alma,Fernandez De La Pradilla, Roberto,Lopez-Rodriguez, Maria L.,Garcia, Ana,Flores, Aida,Alonso, Marta
, p. 1542 - 1547 (2007/10/03)
A survey of routes for aminal cleavage of N-sulfinylimidazolidines has been carried out, and selective conditions to cleave the aminal moiety while preserving the sulfinamide group unaltered have been found. Thus, the treatment of enantiopure N-sulfinylimidazolidines with aqueous H3PO 4 in THF affords enantiopure N-sulfinyldiamino esters in excellent yields, while the presence of MeOH as cosolvent allows for the simultaneous removal of the sulfinamide group and aminal cleavage. The behavior of these substrates in a variety of chemical transformations has been explored.
