675124-90-0

Basic information

• Product Name: L-Leucine, 3-[[(S)-(4-methylphenyl)sulfinyl]amino]-, methyl ester, (3R)-
• CAS NO: 675124-90-0
• Molecular Formula: C14H22N2O3S
• Molecular Weight: 298.406
• Mol File: 675124-90-0.mol

Chemical Properties

• CAS DataBase Reference: L-Leucine, 3-[[(S)-(4-methylphenyl)sulfinyl]amino]-, methyl ester, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, 3-[[(S)-(4-methylphenyl)sulfinyl]amino]-, methyl ester, (3R)-(675124-90-0)
• EPA Substance Registry System: L-Leucine, 3-[[(S)-(4-methylphenyl)sulfinyl]amino]-, methyl ester, (3R)-(675124-90-0)

Safety Data

• Hazardous Substances Data: 675124-90-0(Hazardous Substances Data)

Upstream product

• 596823-44-8 (+)-methyl [(2S,4S,5R,S_S)-2-phenyl-5-(i-propyl)-1-(p-tolylsulfinyl)-1,3-imidazolidin-4-yl]carboxylate 

Downstream Products

• 1157953-13-3 (+)-methyl [(2S,3R,S(S))-4-methyl-2-(p-nitrophenylsulfonylamino)-3-(p-tolylsulfinylamino)]pentanoate 
• 1157953-17-7 (+)-methyl [(2S,3R,S(S))-2-(p-bromophenylsulfonylamino)-4-methyl-3-(p-tolylsulfinylamino)]pentanoate 
• 1157953-20-2 (+)-methyl [(2S,3R,S(S))-4-methyl-2-(p-methoxyphenylsulfonylamino)-3-(p-tolylsulfinylamino)]pentanoate 
• 1157953-06-4 (+)-methyl [(2S,3R,S(S))-4-methyl-3-(p-tolylsulfinylamino)-2-(p-tolylsulfonylamino)]pentanoate 
• 1157953-28-0 (+)-methyl {(2S,3R,S(S))-2-[(1R,4S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl-methylsulfonylamino]-4-methyl-3-(p-tolylsulfinylamino)}pentanoate 
• 1157953-08-6 (-)-methyl [(2S,3R,S(S))-4-methyl-2-(methylsulfonylamino)-3-(p-tolylsulfinylamino)]pentanoate 
• 1157953-26-8 (+)-methyl {(2S,3R,S(S))-2-[(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl-methylsulfonylamino]-4-methyl-3-(p-tolylsulfinylamino)}pentanoate 
• 1157953-21-3 (+)-methyl [(2S,3R,S(S))-2-(3,5-dichloro-2-hydroxyphenylsulfonylamino)-4-methyl-3-(p-tolylsulfinylamino)]pentanoate 
• 1157953-14-4 (+)-methyl [(2S,3R,S(S))-2-(2,4-dinitrophenylsulfonylamino)-4-methyl-3-(p-tolylsulfinylamino)]pentanoate 
• 675124-91-1 (+)-methyl [(2S,3R)-2,3-diamino-4-methyl]pentanoate 
• 1157953-23-5 (+)-methyl [(2S,3R,S(S))-4-methyl-2-(1-naphthylsulfonylamino)-3-(p-tolylsulfinylamino)]pentanoate 
• 1157953-11-1 (+)-methyl [(2S,3R,S(S))-4-methyl-3-(p-tolylsulfinylamino)-2-(2,3,6-triisopropylphenylsulfonylamino)]pentanoate 
• 1157952-84-5 (+)-methyl [(2S,3R,S(S))-N-(diphenylmethylene)-4-methyl-3-(p-tolylsulfinylamino)]pentanoate 

Relevant articles and documents

Synthesis of chiral sulfinamido-sulfonamides and their evaluation as ligands for the enantioselective ethylation of aldehydes

A family of chiral sulfinamido-sulfonamide ligands have been synthesized from sulfinimines and has been evaluated as ligands for the enantioselective addition of diethylzinc to aldehydes with Ti(OiPr)4. The structure of these diamino compounds has been systematically modified to optimize the results.

Fine-Tuned Aminal Cleavage: A Concise Route to Differentially Protected Enantiopure syn-α,β-Diamino Esters

A survey of routes for aminal cleavage of N-sulfinylimidazolidines has been carried out, and selective conditions to cleave the aminal moiety while preserving the sulfinamide group unaltered have been found. Thus, the treatment of enantiopure N-sulfinylimidazolidines with aqueous H3PO 4 in THF affords enantiopure N-sulfinyldiamino esters in excellent yields, while the presence of MeOH as cosolvent allows for the simultaneous removal of the sulfinamide group and aminal cleavage. The behavior of these substrates in a variety of chemical transformations has been explored.