675202-46-7Relevant academic research and scientific papers
Lithiation of N-Boc-protected ferrocenylalkylamines: Preparation of unsymmetrical 1,1′-disubstituted ferrocenes
Chong, J. Michael,Hegedus, Louis S.
, p. 1010 - 1014 (2004)
Treatment of N-Boc-1-ferrocenylethylamine or N-Boc-ferrocenylmethylamine with 2 equiv of n-BuLi results in selective N,1′-dimetalation. Trapping of the dianions with various electrophiles is a convenient route to unsymmetrical 1,1′-disubstituted ferrocenes. Under similar conditions, the pivalamide of 1-ferrocenylethylamine undergoes predominantly N,2-dilithiation while urea derivatives give mixtures of regioisomers.
