67525-35-3Relevant academic research and scientific papers
Quinoline derivative as well as preparation method and application thereof (by machine translation)
-
Paragraph 0261; 0263-0268, (2019/11/28)
The invention provides a quinoline derivative and a composition containing the same. The invention also provides a method for preparing the derivative and application of the derivative and the composition to kill pests. (by machine translation)
Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase
Chen, Zheng,Wu, Yiran,Liu, Ying,Yang, Suijia,Chen, Yunjie,Lai, Luhua
experimental part, p. 3650 - 3660 (2011/07/08)
Dual target inhibitors against COX-2 and LTA4H were designed by adding functional groups from a marketed COX-2 inhibitor, Nimesulide, to an existing LTA4H inhibitor 1-(2-(4-phenoxyphenoxy) ethyl) pyrrolidine. A series of phenoxyphenyl pyrrolidine compounds were synthesized and tested for their inhibition activities using enzyme assays and human whole blood assay. Introduction of small electron withdrawing groups like NO2 and CF3 in the ortho-position of the terminal phenyl ring was found to change the original single target LTA4H inhibitor to dual target LTA4H and COX-2 inhibitors. Compound 5a and 5m showed dual LTA 4H and COX-2 inhibition activities in the enzyme assays and the HWB assay with IC50 values in the micromolar to submicromolar range. As their activities in HWB assay were comparable to the two starting single target inhibitors, the two compounds are promising for further studies. The strategy used in the current study may be generally applicable to other dual target drug designs.
Process for the manufacture of diphenyl ethers
-
, (2008/06/13)
Hydroquinone mono-phenyl ethers, and their alkali metal salts of the formula STR1 in which one of the radicals R1 and R2 denotes trifluoromethyl and the other denotes hydrogen or halogen and R3 represents hydrogen or an alkali metal cation or ammonium cation are prepared by reacting hydroquinone bis-phenyl ethers (bisphenoxybenzenes) of the formula STR2 with hydroquinone derivatives of the formula STR3 in which Cat denotes an alkali metal cation or ammonium cation and R4 denotes an alkali metal cation or ammonium cation or a (C1 -C4)-alkyl group, in a polar aprotic solvent at temperatures from 120° to 280° C., and optionally, an alkyl group present in the R4 -position is split off by treatment with an acid.
