67526-44-7

Basic information

• Product Name: N-phenyl-2-(pyridin-4-ylmethylidene)hydrazinecarbothioamide
• CAS NO: 67526-44-7
• Molecular Formula: C₁₃H₁₂N₄S
• Molecular Weight: 256.3262
• Mol File: 67526-44-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 412.5°C at 760 mmHg
• Flash Point: 203.3°C
• Density: 1.2g/cm³
• Vapor Pressure: 5.14E-07mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: N-phenyl-2-(pyridin-4-ylmethylidene)hydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenyl-2-(pyridin-4-ylmethylidene)hydrazinecarbothioamide(67526-44-7)
• EPA Substance Registry System: N-phenyl-2-(pyridin-4-ylmethylidene)hydrazinecarbothioamide(67526-44-7)

Safety Data

• Hazardous Substances Data: 67526-44-7(Hazardous Substances Data)

Usage

General Description

N-phenyl-2-(pyridin-4-ylmethylidene)hydrazinecarbothioamide is a chemical compound with the molecular formula C13H11N5S. It is a hydrazine derivative with a phenyl group and a pyridine ring attached to a central carbon atom, as well as a thioamide group. N-phenyl-2-(pyridin-4-ylmethylidene)hydrazinecarbothioamide has potential applications in medicinal chemistry, specifically in the development of new drug molecules due to its unique structure and potential biological activity. N-phenyl-2-(pyridin-4-ylmethylidene)hydrazinecarbothioamide may have potential use as a therapeutic agent in the treatment of various diseases, and further research is needed to explore its pharmacological properties and potential uses in the pharmaceutical industry.

Upstream product

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Relevant articles and documents

Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents

In this paper, a series of thiosemicarbazone derivatives containing different aromatic heterocyclic groups were synthesized and the tridentate donor system of the lead compound was optimized. Most of the target compounds showed improved antiproliferative activity against MGC803 cells. SAR studies revealed that compound 5d displayed significant advantages in inhibition effect with an IC50 value of 0.031 μM, and better selectivity between cancer and normal cells than 3-AP and DpC (about 15- and 5-fold improved respectively). Besides, compound 5d showed selective antiproliferative activity in not only other cancer cells but also different gastric cancer cell lines. In-depth mechanism studies showed that compound 5d could induce mitochondria-related apoptosis which might be related to the elevation of intracellular ROS level, and cause cell cycle arrest at S phase. Moreover, 5d could evidently suppress the cell migration and invasion by blocking the EMT (epithelial–mesenchymal transition) process. Consequently, our studies provided a lead optimization strategy of thiosemicarbazone derivatives which would contribute to discover high-efficiency and low-toxicity agents for the treatment of gastric cancer.