675624-07-4Relevant academic research and scientific papers
Structural investigation of the binding of 5-substituted swainsonine analogues to golgi α-mannosidase II
Kuntz, Douglas A.,Nakayama, Shinichi,Shea, Kayla,Hori, Hitoshi,Uto, Yoshihiro,Nagasawa, Hideko,Rose, David R.
experimental part, p. 673 - 680 (2011/03/17)
Golgi α-mannosidase II (GMII) is a key enzyme in the N-glycosylation pathway and is a potential target for cancer chemotherapy. The natural product swainsonine is a potent inhibitor of GMII. In this paper we characterize the binding of 5α-substituted swai
Synthesis of the new mannosidase inhibitors, diversity-oriented 5-substituted swainsonine analogues, via stereoselective mannich reaction
Fujita, Tomoya,Nagasawa, Hideko,Uto, Yoshihiro,Hashimoto, Toshihiro,Asakawa, Yoshinori,Hori, Hitoshi
, p. 827 - 830 (2007/10/03)
5α-Substituted swainsonine analogues were synthesized by Mannich reaction of an in situ generated (-)-swainsonine iminium ion intermediate. 5α-Substituted swainsonine analogues were epimerized to their 5β-isomers in protic solvent.
