67564-53-8Relevant academic research and scientific papers
Enantioselective hydrophosphonylation ofN-Boc imines using chiral guanidine-thiourea catalysts
Chassillan, Louis,Guillot, Régis,Kobayashi, Shū,Toffano, Martial,Vo-Thanh, Giang,Yamashita, Yasuhiro,Yoo, Woo-Jin
supporting information, p. 10560 - 10564 (2021/12/27)
The enantioselective hydrophosphonylation ofN-Boc imines was investigated using a new family of pseudo-symmetric guanidine-thiourea catalysts, providing α-amino phosphonates in moderate to high yields with good enantioselectivity. The catalyst was heterogenized by polymerization with styrene and the resulting catalyst was applied to reactions under continuous-flow conditions.
Asymmetric hydrophosphylation of chiral n-phosphonyl imines provides an efficient approach to chiral α-amino phosphonates
Kaur, Parminder,Wever, Walter,Rajale, Trideep,Li, Guigen
, p. 314 - 319 (2011/12/22)
Chiral N-phosphonylimines were found to react with lithium phosphites to provide various substituted chiral α-amino phosphonates in excellent yields (94-97%) and diastereoselectivities (93:7-99:1). The types of bases utilized for generating the nucleophil
