675845-92-8Relevant academic research and scientific papers
Structure-Activity Relationships of Potent, Selective Inhibitors of Neuronal Nitric Oxide Synthase Based on the 6-Phenyl-2-aminopyridine Structure
Lowe III, John A.,Qian, Weimin,Drozda, Susan E.,Volkmann, Robert A.,Nason, Deane,Nelson, Robert B.,Nolan, Charles,Liston, Dane,Ward, Karen,Faraci, Steve,Verdries, Kim,Seymour, Pat,Majchrzak, Michael,Villalobos, Anabella,White, W. Frost
, p. 1575 - 1586 (2007/10/03)
The synthesis and structure-activity relationships of a series of 6-phenyl-2-aminopyridines that potently and selectively inhibit the neuronal isoform of nitric oxide synthase (nNOS) are described. Compound 14bi from this series exhibits potent in vivo activity in harmaline-induced cGMP formation in rat cerebellum, a functional model of nNOS inhibition, and in the PCP-induced hypermotility model in the rat. These results suggest that 14bi may be a useful reagent for evaluating potential therapeutic applications of nNOS inhibitors in the central nervous system.
