67590-35-6Relevant academic research and scientific papers
DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS
-
Page/Page column 84, (2013/10/22)
Derivatives of purine, 3H-imidazo[4,5-b]pyrimidine and 1H- imidazo[4,5-d]pyrazine of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.
Synthesis of 3,3-disubstituted oxetane building blocks
Vigo, Daniele,Stasi, Luigi,Gagliardi, Stefania
scheme or table, p. 565 - 567 (2011/03/18)
The synthesis of two different sets of 3,3-disubstituted oxetane building blocks is described. These molecules can be usefully incorporated in more complex structures to modulate their metabolic and physicochemical properties. The synthetic pathways are g
Trivalent cluster mannosides with aromatic partial structure as ligands for the type 1 fimbrial lectin of Escherichia coli
R?ckendorf, Niels,Sperling, Oliver,Lindhorst, Thisbe K.
, p. 87 - 93 (2007/10/03)
Mannose-specific adhesion of E. coli bacteria to their host cells is mediated by so-called type 1 fimbriae containing lectin domains present on the type 1 fimbrial FimH protein. The crystal structure of a FimH-FimC(chaperone) protein complex revealed a nu
Synthesis and Complex Chemistry of Functionalised Tripod Ligands RC(CH2PPh2)3
Janssen, Bernd C.,Sernau, Volker,Huttner, Gottfried,Asam, Alexander,Walter, Olaf,et al.
, p. 63 - 70 (2007/10/02)
Malonic ester 1 is alkylated and converted into the triols RC(CH2OH)3 (5).These are easily converted into the corresponding functionalised tripodal ligands RC(CH2PPh2)3 (7) with R = Bzl (a), n-C12H25 (b), (CH3)2CH(CH2)2 (c).Crystals suitable for X-ray crystallography have been obtained of the ligand 7a.In addition, the tripod ligands 7a and 7c have been further characterized by the syntheses and X-ray analyses of the nickel complex (8a), the iron complex (BF4)2 ; and the cobalt complex >(BPh4)(10*BF4). - Key Words: Tripod ligand synthesis / Tripod nickel chloro complexes / Tripod iron tris(acetonitrile) complexes / Tripod cobalt acetate complexes
