6760-41-4

Usage

Chemical Family

Belongs to the quinoline family

Chemical Structure

Consists of a quinoline ring with a nitro group at position 6 and two methyl groups at position 1 and 4

Potential Applications

May have potential applications in the pharmaceutical and agrochemical industries

Structural Features

Nitro group at position 6 and methyl groups at position 1 and 4

Biological Activity

Potential biological activity due to its structural features

Further Research

Further research and studies are needed to explore its potential uses and properties

Molecular Weight

Approximately 219.21 g/mol

Appearance

Yellow to light brown crystalline solid

Solubility

Soluble in organic solvents such as ethanol, methanol, and acetone

Stability

Stable under normal temperature and pressure conditions

Reactivity

May react with strong acids, bases, and reducing agents

Toxicity

Information on toxicity is not provided in the material, but it is important to consider potential hazards when handling 1,4-dimethyl-6-nitroquinolin-2(1H)-one

Environmental Impact

Information on environmental impact is not provided in the material, but it is important to consider potential effects on the environment when handling and disposing of 1,4-dimethyl-6-nitroquinolin-2(1H)-one

Storage

Should be stored in a cool, dry, and well-ventilated area, away from heat, sparks, and open flames, and in a sealed container to prevent contamination and degradation.

Upstream product

• 2584-47-6 1,4-dimethylquinolin-2(1H)-one 
• 102235-76-7 N-Methyl-4'-nitro-1,2-propadien-1-carboxanilid 
• 23543-31-9 2-bromo-N-methyl-N-(4-nitrophenyl)acetamide 
• 100-15-2 N-methyl(p-nitroaniline) 
• 102235-94-9 triphenylphosphoniumbromid 
• 100-61-8 N-methylaniline 
• 2584-48-7 N-methyl-3-oxo-N-phenylbutanamide 

Downstream Products

• 6759-51-9 6-amino-1,4-dimethylquinolin-2(1H)-one 

Relevant academic research and scientific papers

Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins

The bromodomain and plant homeodomain finger-containing (BRPF) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family to chromatin. Here, we describe NI-57 (16) as new pan-BRPF chemical probe of the bromodomain (BRD) of the BRPFs. Inhibitor 16 preferentially bound the BRD of BRPF1 and BRPF2 over BRPF3, whereas binding to BRD9 was weaker. Compound 16 has excellent selectivity over nonclass IV BRD proteins. Target engagement of BRPF1B and BRPF2 with 16 was demonstrated in nanoBRET and FRAP assays. The binding of 16 to BRPF1B was rationalized through an X-ray cocrystal structure determination, which showed a flipped binding orientation when compared to previous structures. We report studies that show 16 has functional activity in cellular assays by modulation of the phenotype at low micromolar concentrations in both cancer and inflammatory models. Pharmacokinetic data for 16 was generated in mouse with single dose administration showing favorable oral bioavailability.

QUINOLONES AS INHIBITORS OF CLASS IV BROMODOMAIN PROTEINS

The present invention provides compounds of formula (I) as described herein and pharmaceutically acceptable salts, hydrates and solvates thereof for use in medicine, for example in the treatment of acute myeloid leukaemia:

Cycloadditions, 15. - Influence of Substituents in p-, m-, and o-Position of the Arene onto the Intramolecular Diels-Alder Reaction of Allenecarboxylic Acid Anilides and Phenyl Esters

The ylides 3 and 8 (synthesized via the bromoacetic acid amides 1 and -esters 6 and via the phosphonium bromides 2 and 7) react with ketene to give the allenecarboxanilides 4 and the phenyl allenecarboxylates 9.Thermolysis in boiling xylene of all derivat

Cycloadditions, 7. Intramolecular Diels-Alder Reactions of Allenecarboxanilides; Variation of the Substituents in the p-Position of the Aniline Nucleus

The N-methyl-1,2-propadiene-1-carboxanilides 6a-h, differently substituted in the p-position, are synthesized by Wittig reaction of the carbamoylmethylenephosphoranes 5 with ketene.They isomerize by thermolysis in boiling xylene to give the tricycles 7a-h, the products of the intramolecular Diels-Alder reaction, and in some cases also to the quinolones 9, the products of a cyclization reaction.The order of the reaction and the influence of the substituents upon the rate of the intramolecular Diels -Alder reaction are determined by 1H-NMR spectroscopy.