676095-46-8Relevant academic research and scientific papers
TRIAZOLE DERIVATIVE OR SALT THEREOF
-
Page/Page column 20; 35, (2009/01/20)
[Problem] To provide a compound which may be used in treating diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, especially diabetes and insulin resistance. [Means for Solution] It was found that a triazole derivative or a pharmaceutically acceptable salt thereof, in which the 3-position of triazole ring is substituted with a trisubstituted methyl group and the 5-position is substituted with a lower alkyl, cycloalkyl or the like, has a strong 11β-HSD1-inhibitory activity. In addition, since the triazole derivative of the present invention shows excellent blood glucose-lowering action, it may be used in the treatment of diabetes and insulin resistance.
An efficient sequence for the preparation of small secondary amine hydrochloride salts for focused library generation without need for distillation or chromatographic purification
Dubowchik, Gene M.,Michne, Jodi A.,Zuev, Dmitry
, p. 3147 - 3149 (2007/10/03)
Collections of small secondary amines for compound library generation can be efficiently prepared by amide reduction using BH3-THF or Red-Al followed by brief methanolysis, trapping with di-tert-butyl dicarbonate, and deprotection with 4M HCl i
The chemistry of tetrafluoroallene: Nucleophilic addition reactions with phenols and amines
Xiao, Ji-Chang,Chen, Qing-Yun
, p. 189 - 195 (2007/10/03)
Treatment of tetrafluoroallene or its precursor, ICF2 CH2CF2I, with phenols in the presence of K2CO3 gave the corresponding unsaturated ethers. Tetrafluoroallene also reacted readily with amines in TH
