Cas 676135-15-2,N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{8-(3-isopropylphenyl)-1 ,4-dioxa-spiro[4.5]decane-8-amino}propyl)acetamide

676135-15-2

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Basic information

Product Name: N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{8-(3-isopropylphenyl)-1 ,4-dioxa-spiro[4.5]decane-8-amino}propyl)acetamide
Synonyms: N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{8-(3-isopropylphenyl)-1 ,4-dioxa-spiro[4.5]decane-8-amino}propyl)acetamide
CAS NO:676135-15-2
Molecular Formula:
Molecular Weight: 516.629
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{8-(3-isopropylphenyl)-1 ,4-dioxa-spiro[4.5]decane-8-amino}propyl)acetamide(CAS DataBase Reference)
NIST Chemistry Reference: N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{8-(3-isopropylphenyl)-1 ,4-dioxa-spiro[4.5]decane-8-amino}propyl)acetamide(676135-15-2)
EPA Substance Registry System: N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{8-(3-isopropylphenyl)-1 ,4-dioxa-spiro[4.5]decane-8-amino}propyl)acetamide(676135-15-2)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 676135-15-2(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 676135-15-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,7,6,1,3 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 676135-15:
(8*6)+(7*7)+(6*6)+(5*1)+(4*3)+(3*5)+(2*1)+(1*5)=172
172 % 10 = 2
So 676135-15-2 is a valid CAS Registry Number.

676135-15-2Upstream product

676135-14-1 tert-butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{8-(3-isopropylphenyl)-1,4-dioxa-spiro[4.5]decane-8-amino}propylcarbamate

676135-15-2Downstream Products

676135-15-2Relevant academic research and scientific papers

OXIME DERIVATIVE HYDROXYETHYLAMINE ASPARTYL-PROTEASE INHIBITORS

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Page/Page column 84-86, (2010/02/15)

The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

OXIME DERIVATIVE SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS

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Page/Page column 86, (2008/06/13)

The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a colletion of diseases, disorders, and conditions associated with abnormal deposition of A-beta protei

2-AMINO- AND 2-THIO-SUBSTITUTED 1,3-DIAMINOPROPANES

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Page/Page column 188, (2008/06/13)

Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer’s disease and other diseases characterized by deposition of A beta peptide in a mammal.

METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INHIBITORS

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Page/Page column 169, (2010/02/13)

The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

SUBSTITUTED UREA AND CARBAMATE, PHENACYL-2-HYDROXY-3-DIAMINOALKANE, AND BENZAMIDE-2-HYDROXY-3-DIAMINOALKANE ASPARTYL-PROTEASE INHIBITORS

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Page/Page column 166, (2010/02/14)

The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating at least one disease, disorder, and condition associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and condition associated with abnormal deposition of A-beta protein.

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