676140-22-0

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 330552-33-5 (3-methyl-2-oxo-2H-quinoxalin-1-yl)-acetyl azide 
• 129886-28-8 1-(3-Methyl-2(1H)-quinoxalinonyl)acetic acid hydrazide 
• 676140-37-7 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetic acid 

Downstream Products

• 676140-45-7 2-[2-(3-methyl-2-oxo-2H-quinoxalin-1-yl)-acetylamino]-3-phenyl-propionamide 
• 676140-40-2 N-(1-hydrazinocarbonyl-2-phenyl-ethyl)-2-(3-methyl-2-oxo-2H-quinoxalin-1-yl)-acetamide 
• 1221568-16-6 (S)-2-(2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamido)-3-phenylpropanoic acid 

Relevant academic research and scientific papers

Novel matrix metalloproteinase inhibitors derived from quinoxalinone scaffold (Part I)

A series of quinoxalinone peptidomimetic derivatives was designed, synthesized, and assayed for their inhibitory activities on metalloproteinase-2 (MMP-2) and aminopeptidase N (APN). The results showed that all of these quinoxalinone derivatives displayed highly selective inhibition against MMP-2 as compared with APN, with IC50 values in the micromole range. Compound A3 showed comparable MMP-2 inhibitory activities than the positive control LY52, which might be used as a potential lead in future research on anticancer agents.

Synthesis and antimicrobial activities of some quinoxalinonyl amino acid and peptide derivatives

The synthesis and antimicrobial screening of some 3-methyl-2 (1H)-quinoxalinon-1-yl acetyl amino acid, peptide, diamine, thiazolyl and benzothiazolyl derivatives, in addition to three copper complexes, have been described. The synthesized compounds have s