676235-49-7Relevant academic research and scientific papers
Design of small molecule ketoamide-based inhibitors of cathepsin K
Catalano, John G.,Deaton, David N.,Long, Stacey T.,McFadyen, Robert B.,Miller, Larry R.,Payne, J. Alan,Wells-Knecht, Kevin J.,Wright, Lois L.
, p. 719 - 722 (2007/10/03)
A novel series of ketoamide-based inhibitors of cathepsin K has been identified. Modifications to P2 and P3 elements were crucial to enhancing inhibitory activity. Although not optimized, a selected inhibitor was effective in attenua
