676236-12-7Relevant articles and documents
Synthesis of 14,15-epoxyisoprostane A2 phosphorylcholine
Acharya, Hukum P.,Miyoshi, Kei,Takashima, Yuji,Ogawa, Narihito,Kobayashi, Yuichi
experimental part, p. 1181 - 1189 (2009/07/05)
The product of the copper-promoted allylic substitution of the 4-hydroxycyclopent-2-enyl ester with TMS-C{triple bond, long}CCH2MgBr was converted to the cyclopentenone with the PMBO(CH2)4CH{double bond, long}CHCH2 side ch
METHOD FOR PRODUCING PROSTAGLANDIN DERIVATIVE, PROSTAGLANDIN DERIVATIVE, INTERMEDIATE COMPOUND THEREFOR AND METHOD FOR PRODUCING THE SAME
-
Page/Page column 25, (2010/02/15)
PROBLEM TO BE SOLVED: To provide a method for producing a prostaglandin derivative, the prostaglandin derivative and an intermediate compound therefor, especially a method for producing a δ-12-prostaglandin J2 derivative using a new method for chemical synthesis through the intermediate compound. SOLUTION: The method for production is a method for producing the prostaglandin derivative using (1R,3R)-4-cyclopentene-1,3-diol 3-acetate (carboxylate) as a starting material. The method is composed of (A) an α-side chain introduction step of providing a malonic acid ester addition compound at the 3-position of the (1R,3R)-4-cyclopentene-1,3-diol, (B) an α-side chain extension step of affording a (1R,3R)-4-cyclopenten-1-one compound having the α-side chain of the prostaglandin derivative at the 3-position and (C) a prostaglandin derivative synthesizing step of conversion into the prostaglandin derivative.