67625-00-7Relevant academic research and scientific papers
Structure-activity relationships in a series of 2,6-dichloro analogs of lidocaine
Ehrhardt,Rouot,Schwartz
, p. 235 - 240 (2007/10/06)
The antiarrhythmic activity of 18 2,6-dichloro analogues of lidocaine was correlated with their pKa and the steric hindrance of the substituent in position 4. The local anaesthesic activity of 11 of them was correlated with their solubility and the electronic and lipophilic constants of the substituents in position 2, 4 and 6.
