67625-75-6

Upstream product

• 58886-81-0 1-(2-cyanoethyl)-1-formylcyclohexane 
• 107-21-1 ethylene glycol 
• 1026642-60-3 3-[1-(tert-butylimino-methyl)-cyclohexyl]-propionitrile 
• 2043-61-0 cyclohexanecarbaldehyde 
• 53188-66-2 N-(cyclohexylmethylene)-2-methylpropan-2-amine 

Downstream Products

• 250347-99-0 3-(1-[1,3]dioxolan-2-yl-cyclohexyl)-1-ethyl-propylamine 
• 105599-49-3 N-(2-azaspiro 5,5 undecanyl)-N'-phenylurea 
• 180-48-3 2-azaspiro<5,5>undecane 
• 261917-68-4 rac-3-Phenyl-2-azaspiro[5.5]undec-1-ene 
• 713510-61-3 4-benzyloxy-N-[3-(1-[1,3]dioxolan-2-yl-cyclohexyl)-propyl]-3-hydroxy-butyramide 
• 713510-60-2 N-[3-(1-[1,3]dioxolan-2-yl-cyclohexyl)-propyl]-3-hydroxy-propionamide 
• 105599-56-2 3-(1-[1,3]Dioxolan-2-yl-cyclohexyl)-propylamine 

Relevant academic research and scientific papers

A stannous chloride-induced deacetalisation-cyclisation process to prepare the ABC ring system of 'upenamide

A stannous chloride-induced deacetalisation-cyclisation approach to the ABC core of the macrocyclic alkaloid, 'upenamide is reported. The use of a substituted β-lactone to prepare a C-2 substituted 'upenamide analogue is also disclosed.

The synthesis of novel cyclic β-amino acids as intermediates for the preparation of bicyclic β-lactams

Several derivatives of homopipecolic acid are prepared by α-amino alkylation of malonic acid with cyclic imines 6 and 7. These are prepared on a large scale and with different substitution patterns. The β-amino acids 8 and 9 were formed in high yield and with remarkable diastereoselectivity if chiral imines are used as starting materials. The diastereoselectivity of the amino alkylation leading to homopipecolic acid analogues is compared to those of thiazolidineacetic acids by epimerisation experiments. A method for resolution of the obtained racemic β-amino acids by diastereomeric salt formation is described. The β-amino acids 9 and 15 were converted into their corresponding carbacepham analogues 14 and isopenam 16. The isopenam endo-16 was selectively epimerised by mild basic treatment of the N/S-acetal to give an exo-configured precursor of isopenicillin G.

Azaspiro compounds

This invention relates to a method of using compounds selected from those of the following formula : STR1 wherein R1 is hydrogen, alkyl or alkenyl; R2 is hydrogen, alkyl, cycloalkyl or mononuclear aryl or R1 and R2/s

Azaspiro compounds

This invention relates to a method of using compounds of the formula: STR1 wherein R1 is hydrogen, alkyl or alkenyl; R2 is hydrogen, alkyl, cycloalkyl or mononuclear aryl or R1 and R2, taken together with the ca