676260-44-9

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 676260-43-8 p-methylphenyl 3-O-p-methoxybenzyl-1-thio-β-D-mannopyranoside 
• 13242-53-0 acetobromomannose 
• 358681-69-3 p-methylphenyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-mannopyranoside 
• 676260-42-7 (2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-(p-tolylthio)tetrahydro-2H-pyran-3,4,5-triol 
• 824-94-2 p-methoxybenzyl chloride 
• 106-45-6 para-thiocresol 

Downstream Products

• 676260-28-9 p-methylphenyl 2-azido-4,6-O-benzylidene-2-deoxy-3-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside 

Relevant academic research and scientific papers

Novel efficient routes to heparin monosaccharides and disaccharides achieved via regio- and stereoselective glycosidation

A new methodology for the synthesis of heparin building blocks has been developed. We describe novel efficient routes to both L-iduronic acid and D-glucuronic acid acceptors. Glycosylation with thioglycosides donors gave corresponding disaccharides in a regio- and stereoselective fashion. An improved approach to synthesizing azido-glucose thioglycoside donor to render azido-sugar from mannose via nucleophilic substitution is described.