676264-68-9

Upstream product

• 342612-67-3 (S)-3-Cyclohexyl-2-((2S,3S)-3-methyl-2-{(S)-4-methyl-2-[(pyrazine-2-carbonyl)-amino]-pentanoylamino}-pentanoylamino)-propionic acid 
• 676262-11-6 (S)-2-[(2S,3S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-pentanoylamino]-3-cyclohexyl-propionic acid 
• 342612-66-2 (S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-cyclohexyl-propionic acid 
• 676261-87-3 (S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-cyclohexyl-propionic acid 
• 3392-08-3 N-(tert-butoxy)carbonyl-L-isoleucine N-hydroxysuccinimide ester 
• 27527-05-5 L-cyclohexylalanine 
• 3392-09-4 Boc-Leu-ONSu 
• 558475-55-1 (S)-3-[(S)-3-Cyclohexyl-2-((2S,3S)-3-methyl-2-{(S)-4-methyl-2-[(pyrazine-2-carbonyl)-amino]-pentanoylamino}-pentanoylamino)-propionylamino]-5,5-difluoro-2-hydroxy-pentanoic acid methyl ester 
• 676262-42-3 (S)-2-[(2S,3S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-pentanoylamino]-3-cyclohexyl-propionic acid 

Downstream Products

• 342611-60-3 {(S)-3-[(S)-3-Cyclohexyl-2-((2S,3S)-3-methyl-2-{(S)-4-methyl-2-[(pyrazine-2-carbonyl)-amino]-pentanoylamino}-pentanoylamino)-propionylamino]-5,5-difluoro-2-oxo-pentanoylamino}-acetic acid 
• 676264-71-4 {(S)-3-[(S)-3-Cyclohexyl-2-((2S,3S)-3-methyl-2-{(S)-4-methyl-2-[(pyrazine-2-carbonyl)-amino]-pentanoylamino}-pentanoylamino)-propionylamino]-5,5-difluoro-2-oxo-pentanoylamino}-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Investigation of glycine α-ketoamide HCV NS3 protease inhibitors: Effect of carboxylic acid isosteres

The design and synthesis of tetrapeptide-based α-ketoamides containing prime side acid isosteres HCV NS3 protease inhibitors are described. Tetrazole, sulfonic acid, and N-sulfonylcarboxamids were demonstrated to be efficient carboxylic acid replacements.

Glycine α-ketoamides as HCV NS3 protease inhibitors

Using a tetrapeptide-based α-ketoamide template, various amines and amino acids were incorporated to explore the prime side of the HCV NS3 protease catalytic site. Glycine carboxylic acid was found to be the most effective prime group. Further optimizatio