67627-60-5Relevant academic research and scientific papers
Efficient Synthesis of Dimeric Oxazoles, Piperidines and Tetrahydroisoquinolines from N-Substituted 2-Oxazolones
He, Yun,Agarwal, Piyush K.,Kiran, I. N. Chaithanya,Yu, Ruocheng,Cao, Bei,Zou, Cheng,Zhou, Xinghua,Xu, Huacheng,Xu, Biao,Zhu, Lei,Lan, Yu,Nicolaou
supporting information, p. 7696 - 7701 (2016/06/09)
A mild and practical method for the construction of heterocycles from N-substituted 2-oxazolones through cascade, BF3·Et2O/H2O-catalyzed reactions involving iminium ion generation and trapping by external or internal olefinic and aryl moieties is described. Mechanistic and computational studies revealed the strong protic acid HBF4as the initiating catalyst for these cascade reactions. Providing access to novel molecular diversity, these processes may facilitate chemical biology studies, drug discovery efforts and natural products synthesis.
Preparation method for oxazolone heterocyclic compounds
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Paragraph 0142; 0143; 0144; 0145, (2017/04/22)
The invention relates to a preparation method for N-substituted oxazolone polymerized compounds. According to the method, the easily available reagent, boron trifluoride ether, is used as a catalyst, and dimerization, cascaded dimerization/cyclization, te
COMPETING DIMERISATION OF SOME N,O-HETEROCYCLICS. THERMODYNAMIC VERSUS KINETIC CONTROL OF ISOMERIC PRODUCTS
Cum, Giampietro,Gianetto, Placido,Sindona, Giovanni,Uccella, Nicola
, p. 745 - 752 (2007/10/02)
The behaviour of substituted 1,3-oxazolidin-2-ones (1) and 1,3-oxazolin-2-ones (2) on treatment with acid is reported.Electrophylic addition of iminium cations to 1,2-oxazolin-2-onic monomers occurs, yielding the kinetically preferred dimers (3).The elimi
